Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR-STAT with CSF suppression
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arXiv
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| Format: | Preprint |
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2024
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| author | Liu, Hongyan Versteeg, Edwin Fuderer, Miha van der Heide, Oscar Schilder, Martin B. Berg, Cornelis A. T. van den Sbrizzi, Alessandro |
| author_facet | Liu, Hongyan Versteeg, Edwin Fuderer, Miha van der Heide, Oscar Schilder, Martin B. Berg, Cornelis A. T. van den Sbrizzi, Alessandro |
| contents | Purpose: Current 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocols use transient-state, gradient-spoiled gradient-echo sequences that are prone to cerebrospinal fluid (CSF) pulsation artifacts when applied to the brain. This study aims at developing a 3D MR-STAT protocol for whole-brain relaxometry that overcomes the challenges posed by CSF-induced ghosting artifacts. Method: We optimized the flip-angle train within the Cartesian 3D MR-STAT framework to achieve two objectives: (1) minimization of the noise level in the reconstructed quantitative maps, and (2) reduction of the CSF-to-white-matter signal ratio to suppress CSF signal and the associated pulsation artifacts. The optimized new sequence was tested on a gel/water-phantom to evaluate the accuracy of the quantitative maps, and on healthy volunteers to explore the effectiveness of the CSF artifact suppression and robustness of the new protocol. Results: A new optimized sequence with both high parameter encoding capability and low CSF intensity was proposed and initially validated in the gel/water-phantom experiment. From in-vivo experiments with five volunteers, the proposed CSF-suppressed sequence shows no CSF ghosting artifacts and overall greatly improved image quality for all quantitative maps compared to the baseline sequence. Statistical analysis indicated low inter-subject and inter-scan variability for quantitative parameters in gray matter and white matter (1.6%-2.4% for T1 and 2.0%-4.6% for T2), demonstrating the robustness of the new sequence. Conclusion: We presented a new 3D MR-STAT sequence with CSF suppression that effectively eliminates CSF pulsation artifacts. The new sequence ensures consistently high-quality, 1mm^3 whole-brain relaxometry within a rapid 5.5-minute scan time. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2403_15379 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR-STAT with CSF suppression Liu, Hongyan Versteeg, Edwin Fuderer, Miha van der Heide, Oscar Schilder, Martin B. Berg, Cornelis A. T. van den Sbrizzi, Alessandro Medical Physics Image and Video Processing Purpose: Current 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocols use transient-state, gradient-spoiled gradient-echo sequences that are prone to cerebrospinal fluid (CSF) pulsation artifacts when applied to the brain. This study aims at developing a 3D MR-STAT protocol for whole-brain relaxometry that overcomes the challenges posed by CSF-induced ghosting artifacts. Method: We optimized the flip-angle train within the Cartesian 3D MR-STAT framework to achieve two objectives: (1) minimization of the noise level in the reconstructed quantitative maps, and (2) reduction of the CSF-to-white-matter signal ratio to suppress CSF signal and the associated pulsation artifacts. The optimized new sequence was tested on a gel/water-phantom to evaluate the accuracy of the quantitative maps, and on healthy volunteers to explore the effectiveness of the CSF artifact suppression and robustness of the new protocol. Results: A new optimized sequence with both high parameter encoding capability and low CSF intensity was proposed and initially validated in the gel/water-phantom experiment. From in-vivo experiments with five volunteers, the proposed CSF-suppressed sequence shows no CSF ghosting artifacts and overall greatly improved image quality for all quantitative maps compared to the baseline sequence. Statistical analysis indicated low inter-subject and inter-scan variability for quantitative parameters in gray matter and white matter (1.6%-2.4% for T1 and 2.0%-4.6% for T2), demonstrating the robustness of the new sequence. Conclusion: We presented a new 3D MR-STAT sequence with CSF suppression that effectively eliminates CSF pulsation artifacts. The new sequence ensures consistently high-quality, 1mm^3 whole-brain relaxometry within a rapid 5.5-minute scan time. |
| title | Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR-STAT with CSF suppression |
| topic | Medical Physics Image and Video Processing |
| url | https://arxiv.org/abs/2403.15379 |