Interpretable cancer cell detection with phonon microscopy using multi-task conditional neural networks for inter-batch calibration
Fuente:
arXiv
Salvato in:
| Autori principali: | , , , , |
|---|---|
| Natura: | Preprint |
| Pubblicazione: |
2024
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866910385770070016 |
|---|---|
| author | Zheng, Yijie Fuentes-Dominguez, Rafael Clark, Matt Gordon, George S. D. Perez-Cota, Fernando |
| author_facet | Zheng, Yijie Fuentes-Dominguez, Rafael Clark, Matt Gordon, George S. D. Perez-Cota, Fernando |
| contents | Advances in artificial intelligence (AI) show great potential in revealing underlying information from phonon microscopy (high-frequency ultrasound) data to identify cancerous cells. However, this technology suffers from the 'batch effect' that comes from unavoidable technical variations between each experiment, creating confounding variables that the AI model may inadvertently learn. We therefore present a multi-task conditional neural network framework to simultaneously achieve inter-batch calibration, by removing confounding variables, and accurate cell classification of time-resolved phonon-derived signals. We validate our approach by training and validating on different experimental batches, achieving a balanced precision of 89.22% and an average cross-validated precision of 89.07% for classifying background, healthy and cancerous regions. Classification can be performed in 0.5 seconds with only simple prior batch information required for multiple batch corrections. Further, we extend our model to reconstruct denoised signals, enabling physical interpretation of salient features indicating disease state including sound velocity, sound attenuation and cell-adhesion to substrate. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_17992 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Interpretable cancer cell detection with phonon microscopy using multi-task conditional neural networks for inter-batch calibration Zheng, Yijie Fuentes-Dominguez, Rafael Clark, Matt Gordon, George S. D. Perez-Cota, Fernando Quantitative Methods Artificial Intelligence Machine Learning Image and Video Processing Signal Processing Advances in artificial intelligence (AI) show great potential in revealing underlying information from phonon microscopy (high-frequency ultrasound) data to identify cancerous cells. However, this technology suffers from the 'batch effect' that comes from unavoidable technical variations between each experiment, creating confounding variables that the AI model may inadvertently learn. We therefore present a multi-task conditional neural network framework to simultaneously achieve inter-batch calibration, by removing confounding variables, and accurate cell classification of time-resolved phonon-derived signals. We validate our approach by training and validating on different experimental batches, achieving a balanced precision of 89.22% and an average cross-validated precision of 89.07% for classifying background, healthy and cancerous regions. Classification can be performed in 0.5 seconds with only simple prior batch information required for multiple batch corrections. Further, we extend our model to reconstruct denoised signals, enabling physical interpretation of salient features indicating disease state including sound velocity, sound attenuation and cell-adhesion to substrate. |
| title | Interpretable cancer cell detection with phonon microscopy using multi-task conditional neural networks for inter-batch calibration |
| topic | Quantitative Methods Artificial Intelligence Machine Learning Image and Video Processing Signal Processing |
| url | https://arxiv.org/abs/2403.17992 |