Ion-Mediated Structural Discontinuities in Phospholipid Vesicles
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arXiv
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| Hauptverfasser: | , , |
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| Format: | Preprint |
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2024
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| _version_ | 1866909154676834304 |
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| author | De Mel, Judith U. Gupta, Sudipta Schneider, Gerald J. |
| author_facet | De Mel, Judith U. Gupta, Sudipta Schneider, Gerald J. |
| contents | Despite intense research, methods for controlling soft matter's spontaneous self-assembly in-to well-defined layers remain a significant challenge. We observed ion-induced structural disconti-nuities of phospholipid vesicles that can be exploited for controlled self-assembly of soft materials. We used dynamic light scattering, zeta-potential measurement, cryo-electron microscopy, small-angle X-ray, and small-angle neutron scattering. All the experimental observations indicate that de-clining solvent quality and increasing osmotic pressure direct lipids to expel preferentially to the inner compartment. Upon reaching a critical concentration, excess lipids can form a new bilayer. This spontaneous self-assembly process causes simultaneous shrinkage of the aqueous core and expansion of the vesicle. This approach opens an intriguing path for controlling the self-assembly of bioinspired colloids, which can also serve as a vehicle to control the polymerization of multilayer polymeric systems. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_19922 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Ion-Mediated Structural Discontinuities in Phospholipid Vesicles De Mel, Judith U. Gupta, Sudipta Schneider, Gerald J. Soft Condensed Matter Despite intense research, methods for controlling soft matter's spontaneous self-assembly in-to well-defined layers remain a significant challenge. We observed ion-induced structural disconti-nuities of phospholipid vesicles that can be exploited for controlled self-assembly of soft materials. We used dynamic light scattering, zeta-potential measurement, cryo-electron microscopy, small-angle X-ray, and small-angle neutron scattering. All the experimental observations indicate that de-clining solvent quality and increasing osmotic pressure direct lipids to expel preferentially to the inner compartment. Upon reaching a critical concentration, excess lipids can form a new bilayer. This spontaneous self-assembly process causes simultaneous shrinkage of the aqueous core and expansion of the vesicle. This approach opens an intriguing path for controlling the self-assembly of bioinspired colloids, which can also serve as a vehicle to control the polymerization of multilayer polymeric systems. |
| title | Ion-Mediated Structural Discontinuities in Phospholipid Vesicles |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2403.19922 |