Dynamics of nano-scale assemblies of amphiphilic PEG-PDMS-PEG copolymers
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arXiv
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| Format: | Preprint |
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2024
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| author | Gupta, Sudipta Perera, Rasangi M. Van Leeuwen, Christopher J. Li, Tianyu Stingaciu, Laura Bleuel, Markus Hong, Kunlun Schneider, Gerald J. |
| author_facet | Gupta, Sudipta Perera, Rasangi M. Van Leeuwen, Christopher J. Li, Tianyu Stingaciu, Laura Bleuel, Markus Hong, Kunlun Schneider, Gerald J. |
| contents | Micelles and vesicles are promising candidates in targeted drug/gene delivery, bioreactors, and templates for nanoparticle synthesis. We investigated the morphology and dynamics of PEG-PDMS-PEG triblock copolymer nano-scale assemblies regarding the membrane dynamics because the molecular dynamics of the membrane govern mechanical properties like the stability of a membrane. We studied the structure by cryogenic transmission electron microscopy, small-angle neutron scattering, and the dynamics by dynamic light scattering and neutron spin echo spectroscopy. We changed the length of the hydrophilic block to obtain micellar and vesicular systems. The vesicle has a membrane rigidity, $κ_η= 16 \pm 2 k_B T$, the same order of magnitude as the corresponding liposome value but one order of magnitude higher than polymeric interfaces in microemulsions. Hence, the height-height fluctuations of polymers in a polymersome seem much less than those measured for surfactants at an oil-water interface. Therefore, the polymersome is substantially more stable. The value is very close to liposomes, indicating a similar stability. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2404_00120 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Dynamics of nano-scale assemblies of amphiphilic PEG-PDMS-PEG copolymers Gupta, Sudipta Perera, Rasangi M. Van Leeuwen, Christopher J. Li, Tianyu Stingaciu, Laura Bleuel, Markus Hong, Kunlun Schneider, Gerald J. Soft Condensed Matter Micelles and vesicles are promising candidates in targeted drug/gene delivery, bioreactors, and templates for nanoparticle synthesis. We investigated the morphology and dynamics of PEG-PDMS-PEG triblock copolymer nano-scale assemblies regarding the membrane dynamics because the molecular dynamics of the membrane govern mechanical properties like the stability of a membrane. We studied the structure by cryogenic transmission electron microscopy, small-angle neutron scattering, and the dynamics by dynamic light scattering and neutron spin echo spectroscopy. We changed the length of the hydrophilic block to obtain micellar and vesicular systems. The vesicle has a membrane rigidity, $κ_η= 16 \pm 2 k_B T$, the same order of magnitude as the corresponding liposome value but one order of magnitude higher than polymeric interfaces in microemulsions. Hence, the height-height fluctuations of polymers in a polymersome seem much less than those measured for surfactants at an oil-water interface. Therefore, the polymersome is substantially more stable. The value is very close to liposomes, indicating a similar stability. |
| title | Dynamics of nano-scale assemblies of amphiphilic PEG-PDMS-PEG copolymers |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2404.00120 |