RNA Dynamics from Experimental and Computational Approaches
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arXiv
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866929491033456640 |
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| author | Bussi, Giovanni Bonomi, Massimiliano Gkeka, Paraskevi Sattler, Michael Al-Hashimi, Hashim M. Auffinger, Pascal Duca, Maria Foricher, Yann Incarnato, Danny Jones, Alisha N. Kirmizialtin, Serdal Krepl, Miroslav Orozco, Modesto Palermo, Giulia Pasquali, Samuela Salmon, Loïc Schwalbe, Harald Westhof, Eric Zacharias, Martin |
| author_facet | Bussi, Giovanni Bonomi, Massimiliano Gkeka, Paraskevi Sattler, Michael Al-Hashimi, Hashim M. Auffinger, Pascal Duca, Maria Foricher, Yann Incarnato, Danny Jones, Alisha N. Kirmizialtin, Serdal Krepl, Miroslav Orozco, Modesto Palermo, Giulia Pasquali, Samuela Salmon, Loïc Schwalbe, Harald Westhof, Eric Zacharias, Martin |
| contents | Ribonucleic acids (RNA) are unique in that they can store genetic information, replicate and perform catalysis. Importantly, RNA molecules are highly dynamic, and thus determining the ensemble of conformations that they populate is crucial not only to elucidate their biological functions, but also for their potential use as therapeutic targets. Computational and experimental techniques provide complementary views on RNA dynamics, and their integration is fundamental to improve the accuracy of computations and the resolution of experiments. Recent exciting developments in this field, were discussed at the CECAM workshop ``RNA dynamics from experimental and computational approaches'', in Paris, June 26-28, 2023. This report outlines key `take-home' messages that emerged during this workshop from the presentations and discussions. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2404_02789 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | RNA Dynamics from Experimental and Computational Approaches Bussi, Giovanni Bonomi, Massimiliano Gkeka, Paraskevi Sattler, Michael Al-Hashimi, Hashim M. Auffinger, Pascal Duca, Maria Foricher, Yann Incarnato, Danny Jones, Alisha N. Kirmizialtin, Serdal Krepl, Miroslav Orozco, Modesto Palermo, Giulia Pasquali, Samuela Salmon, Loïc Schwalbe, Harald Westhof, Eric Zacharias, Martin Biomolecules Biological Physics Ribonucleic acids (RNA) are unique in that they can store genetic information, replicate and perform catalysis. Importantly, RNA molecules are highly dynamic, and thus determining the ensemble of conformations that they populate is crucial not only to elucidate their biological functions, but also for their potential use as therapeutic targets. Computational and experimental techniques provide complementary views on RNA dynamics, and their integration is fundamental to improve the accuracy of computations and the resolution of experiments. Recent exciting developments in this field, were discussed at the CECAM workshop ``RNA dynamics from experimental and computational approaches'', in Paris, June 26-28, 2023. This report outlines key `take-home' messages that emerged during this workshop from the presentations and discussions. |
| title | RNA Dynamics from Experimental and Computational Approaches |
| topic | Biomolecules Biological Physics |
| url | https://arxiv.org/abs/2404.02789 |