Origins of Fine Structure in DNA Melting Curves
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arXiv
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| Autores principales: | , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| _version_ | 1866911834420805632 |
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| author | Asatryan, Arevik V. Benight, Albert S. Badasyan, Artem V. |
| author_facet | Asatryan, Arevik V. Benight, Albert S. Badasyan, Artem V. |
| contents | With the help of one-dimensional random Potts-like model we study the origins of fine structure observed on differential melting profiles of double-stranded DNA. We assess the effects of sequence arrangement on DNA melting curves through the comparison of results for random, correlated, and block sequences. Our results re-confirm the smearing out the fine structure with the increase of chain length for all types of sequence arrangements and suggest fine structure to be a finite-size effect. We have found, that the fine structure in chains comprised of blocks with the correlation in sequence is more persistent, probably, because of increased sequence disorder the blocks introduce. Many natural DNAs show a well-expressed fine structure of melting profiles. In view of our results it might mean the existence of blocks in such DNAs. The very observation of fine structure may also mean, that there exists an optimal length for natural DNAs \emph{in vivo}. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2404_06822 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Origins of Fine Structure in DNA Melting Curves Asatryan, Arevik V. Benight, Albert S. Badasyan, Artem V. Soft Condensed Matter With the help of one-dimensional random Potts-like model we study the origins of fine structure observed on differential melting profiles of double-stranded DNA. We assess the effects of sequence arrangement on DNA melting curves through the comparison of results for random, correlated, and block sequences. Our results re-confirm the smearing out the fine structure with the increase of chain length for all types of sequence arrangements and suggest fine structure to be a finite-size effect. We have found, that the fine structure in chains comprised of blocks with the correlation in sequence is more persistent, probably, because of increased sequence disorder the blocks introduce. Many natural DNAs show a well-expressed fine structure of melting profiles. In view of our results it might mean the existence of blocks in such DNAs. The very observation of fine structure may also mean, that there exists an optimal length for natural DNAs \emph{in vivo}. |
| title | Origins of Fine Structure in DNA Melting Curves |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2404.06822 |