Electroporation-mediated Metformin for effective anticancer treatment of triple-negative breast cancer cells
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arXiv
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| Autores principales: | , , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| _version_ | 1866911849083043840 |
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| author | Sahu, Praveen Camarillo, Ignacio G. Giri, Pragatheiswar Sundararajan, Raji |
| author_facet | Sahu, Praveen Camarillo, Ignacio G. Giri, Pragatheiswar Sundararajan, Raji |
| contents | In this research, we investigated the efficacy of Metformin, the most commonly administered type-2 diabetes drug for triple negative breast cancer (TNBC) treatment, due to its various anticancer properties. It is a plant-based bio-compound, synthesized as a novel biguanide, called dimethyl biguanide or metformin. One of the ways it operates is by hindering electron transport chain-complex I, in mitochondria, which causes a drop-in energy (ATP) generation. This eventually builds energetic stress and a decline in energy. Therefore, the natural cellular processes and proliferating tumor cells are obstructed. Here, we used electroporation, where, the MDA-MB-231, human TNBC cells were subjected to high intensity, short-duration electrical pulses (EP) in the presence of Metformin. The cell viability results indicate lower cell viability of 43.45% as compared to 85.20% with drug alone at 5mM concentration. This indicates that Metformin, the most common diabetes drug could also be explored for cancer treatment. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2404_14353 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Electroporation-mediated Metformin for effective anticancer treatment of triple-negative breast cancer cells Sahu, Praveen Camarillo, Ignacio G. Giri, Pragatheiswar Sundararajan, Raji Biomolecules Cell Behavior In this research, we investigated the efficacy of Metformin, the most commonly administered type-2 diabetes drug for triple negative breast cancer (TNBC) treatment, due to its various anticancer properties. It is a plant-based bio-compound, synthesized as a novel biguanide, called dimethyl biguanide or metformin. One of the ways it operates is by hindering electron transport chain-complex I, in mitochondria, which causes a drop-in energy (ATP) generation. This eventually builds energetic stress and a decline in energy. Therefore, the natural cellular processes and proliferating tumor cells are obstructed. Here, we used electroporation, where, the MDA-MB-231, human TNBC cells were subjected to high intensity, short-duration electrical pulses (EP) in the presence of Metformin. The cell viability results indicate lower cell viability of 43.45% as compared to 85.20% with drug alone at 5mM concentration. This indicates that Metformin, the most common diabetes drug could also be explored for cancer treatment. |
| title | Electroporation-mediated Metformin for effective anticancer treatment of triple-negative breast cancer cells |
| topic | Biomolecules Cell Behavior |
| url | https://arxiv.org/abs/2404.14353 |