Local well-posedness for a novel nonlocal model for cell-cell adhesion via receptor binding
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| Main Authors: | , |
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| Format: | Preprint |
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2024
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| _version_ | 1866908364925042688 |
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| author | Rajendran, Mabel Lizzy Zhigun, Anna |
| author_facet | Rajendran, Mabel Lizzy Zhigun, Anna |
| contents | Local well-posedness is established for a highly nonlocal nonlinear diffusion-adhesion system for bounded initial values with small support. Macroscopic systems of this kind were previously obtained by the authors through upscaling in [32] and can account for the effect of microscopic receptor binding dynamics in cell-cell adhesion. The system analysed here couples an integro-PDE featuring degenerate diffusion of the porous media type and nonlocal adhesion with a novel nonlinear integral equation. The approach is based on decoupling the system and using Banach's fixed point theorem to solve each of the two equations individually and subsequently the entire system. The main challenge of the implementation lies in selecting a suitable framework. One of the key results is the local well-posedness for the integral equation with a Radon measure as a parameter. The analysis of this equation utilizes the Kantorovich-Rubinstein norm, marking the first application of this norm in handling a nonlinear integral equation. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2404_15222 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Local well-posedness for a novel nonlocal model for cell-cell adhesion via receptor binding Rajendran, Mabel Lizzy Zhigun, Anna Analysis of PDEs 35K65 35Q92 45G10 45K05 47G10 92C17 Local well-posedness is established for a highly nonlocal nonlinear diffusion-adhesion system for bounded initial values with small support. Macroscopic systems of this kind were previously obtained by the authors through upscaling in [32] and can account for the effect of microscopic receptor binding dynamics in cell-cell adhesion. The system analysed here couples an integro-PDE featuring degenerate diffusion of the porous media type and nonlocal adhesion with a novel nonlinear integral equation. The approach is based on decoupling the system and using Banach's fixed point theorem to solve each of the two equations individually and subsequently the entire system. The main challenge of the implementation lies in selecting a suitable framework. One of the key results is the local well-posedness for the integral equation with a Radon measure as a parameter. The analysis of this equation utilizes the Kantorovich-Rubinstein norm, marking the first application of this norm in handling a nonlinear integral equation. |
| title | Local well-posedness for a novel nonlocal model for cell-cell adhesion via receptor binding |
| topic | Analysis of PDEs 35K65 35Q92 45G10 45K05 47G10 92C17 |
| url | https://arxiv.org/abs/2404.15222 |