VASARI-auto: equitable, efficient, and economical featurisation of glioma MRI
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| Format: | Preprint |
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2024
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| _version_ | 1866929495654531072 |
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| author | Ruffle, James K Mohinta, Samia Baruteau, Kelly Pegoretti Rajiah, Rebekah Lee, Faith Brandner, Sebastian Nachev, Parashkev Hyare, Harpreet |
| author_facet | Ruffle, James K Mohinta, Samia Baruteau, Kelly Pegoretti Rajiah, Rebekah Lee, Faith Brandner, Sebastian Nachev, Parashkev Hyare, Harpreet |
| contents | The VASARI MRI feature set is a quantitative system designed to standardise glioma imaging descriptions. Though effective, deriving VASARI is time-consuming and seldom used in clinical practice. This is a problem that machine learning could plausibly automate. Using glioma data from 1172 patients, we developed VASARI-auto, an automated labelling software applied to both open-source lesion masks and our openly available tumour segmentation model. In parallel, two consultant neuroradiologists independently quantified VASARI features in a subsample of 100 glioblastoma cases. We quantified: 1) agreement across neuroradiologists and VASARI-auto; 2) calibration of performance equity; 3) an economic workforce analysis; and 4) fidelity in predicting patient survival. Tumour segmentation was compatible with the current state of the art and equally performant regardless of age or sex. A modest inter-rater variability between in-house neuroradiologists was comparable to between neuroradiologists and VASARI-auto, with far higher agreement between VASARI-auto methods. The time taken for neuroradiologists to derive VASARI was substantially higher than VASARI-auto (mean time per case 317 vs. 3 seconds). A UK hospital workforce analysis forecast that three years of VASARI featurisation would demand 29,777 consultant neuroradiologist workforce hours (£1,574,935), reducible to 332 hours of computing time (and £146 of power) with VASARI-auto. The best-performing survival model utilised VASARI-auto features as opposed to those derived by neuroradiologists. VASARI-auto is a highly efficient automated labelling system with equitable performance across patient age or sex, a favourable economic profile if used as a decision support tool, and with non-inferior fidelity in downstream patient survival prediction. Future work should iterate upon and integrate such tools to enhance patient care. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2404_15318 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | VASARI-auto: equitable, efficient, and economical featurisation of glioma MRI Ruffle, James K Mohinta, Samia Baruteau, Kelly Pegoretti Rajiah, Rebekah Lee, Faith Brandner, Sebastian Nachev, Parashkev Hyare, Harpreet Quantitative Methods Computer Vision and Pattern Recognition Tissues and Organs The VASARI MRI feature set is a quantitative system designed to standardise glioma imaging descriptions. Though effective, deriving VASARI is time-consuming and seldom used in clinical practice. This is a problem that machine learning could plausibly automate. Using glioma data from 1172 patients, we developed VASARI-auto, an automated labelling software applied to both open-source lesion masks and our openly available tumour segmentation model. In parallel, two consultant neuroradiologists independently quantified VASARI features in a subsample of 100 glioblastoma cases. We quantified: 1) agreement across neuroradiologists and VASARI-auto; 2) calibration of performance equity; 3) an economic workforce analysis; and 4) fidelity in predicting patient survival. Tumour segmentation was compatible with the current state of the art and equally performant regardless of age or sex. A modest inter-rater variability between in-house neuroradiologists was comparable to between neuroradiologists and VASARI-auto, with far higher agreement between VASARI-auto methods. The time taken for neuroradiologists to derive VASARI was substantially higher than VASARI-auto (mean time per case 317 vs. 3 seconds). A UK hospital workforce analysis forecast that three years of VASARI featurisation would demand 29,777 consultant neuroradiologist workforce hours (£1,574,935), reducible to 332 hours of computing time (and £146 of power) with VASARI-auto. The best-performing survival model utilised VASARI-auto features as opposed to those derived by neuroradiologists. VASARI-auto is a highly efficient automated labelling system with equitable performance across patient age or sex, a favourable economic profile if used as a decision support tool, and with non-inferior fidelity in downstream patient survival prediction. Future work should iterate upon and integrate such tools to enhance patient care. |
| title | VASARI-auto: equitable, efficient, and economical featurisation of glioma MRI |
| topic | Quantitative Methods Computer Vision and Pattern Recognition Tissues and Organs |
| url | https://arxiv.org/abs/2404.15318 |