WATCH: A Workflow to Assess Treatment Effect Heterogeneity in Drug Development for Clinical Trial Sponsors
Fuente:
arXiv
Saved in:
| Main Authors: | Sechidis, Konstantinos, Sun, Sophie, Chen, Yao, Lu, Jiarui, Zhang, Cong, Baillie, Mark, Ohlssen, David, Vandemeulebroecke, Marc, Hemmings, Rob, Ruberg, Stephen, Bornkamp, Björn |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
WATCH: A Workflow to Assess Treatment Effect Heterogeneity in Drug Development for Clinical Trial Sponsors
by: Konstantinos Sechidis, et al.
Published: (2024)
by: Konstantinos Sechidis, et al.
Published: (2024)
Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity
by: Sechidis, Konstantinos, et al.
Published: (2025)
by: Sechidis, Konstantinos, et al.
Published: (2025)
A Workflow for Evaluating Regional Treatment Effect Heterogeneity in Multi-Regional Clinical Trials
by: Zhang, Cong, et al.
Published: (2026)
by: Zhang, Cong, et al.
Published: (2026)
Comparing methods to assess treatment effect heterogeneity in general parametric regression models
by: Chen, Yao, et al.
Published: (2025)
by: Chen, Yao, et al.
Published: (2025)
Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity
by: Konstantinos Sechidis, et al.
Published: (2025)
by: Konstantinos Sechidis, et al.
Published: (2025)
Comparing Methods to Assess Treatment Effect Heterogeneity in General Parametric Regression Models
by: Yao Chen, et al.
Published: (2026)
by: Yao Chen, et al.
Published: (2026)
Predicting subgroup treatment effects for a new study: Motivations, results and learnings from running a data challenge in a pharmaceutical corporation
by: Bornkamp, Björn, et al.
Published: (2023)
by: Bornkamp, Björn, et al.
Published: (2023)
Assessment of evidence against homogeneity in exhaustive subgroup treatment effect plots
by: Bornkamp, Björn, et al.
Published: (2026)
by: Bornkamp, Björn, et al.
Published: (2026)
All that Glitters Is not Gold: Type‐I Error Controlled Variable Selection from Clinical Trial Data
by: Manuela R. Zimmermann, et al.
Published: (2024)
by: Manuela R. Zimmermann, et al.
Published: (2024)
Data-driven controlled subgroup selection in clinical trials
by: Müller, Manuel M., et al.
Published: (2025)
by: Müller, Manuel M., et al.
Published: (2025)
Futility analyses for the MCP-Mod methodology based on longitudinal models
by: Bornkamp, Björn, et al.
Published: (2024)
by: Bornkamp, Björn, et al.
Published: (2024)
Assessing Heterogeneity of Treatment Effects
by: Kaji, Tetsuya, et al.
Published: (2023)
by: Kaji, Tetsuya, et al.
Published: (2023)
Clustering-Based Outcome Models for Clinical Studies: A Scoping Review
by: Vilsmeier, Johannes, et al.
Published: (2026)
by: Vilsmeier, Johannes, et al.
Published: (2026)
Evaluating causal effects on time-to-event outcomes in an RCT in Oncology with treatment discontinuation
by: Ballerini, Veronica, et al.
Published: (2023)
by: Ballerini, Veronica, et al.
Published: (2023)
Uncovering Treatment Effect Heterogeneity in Pragmatic Gerontology Trials
by: Li, Changjun, et al.
Published: (2025)
by: Li, Changjun, et al.
Published: (2025)
Estimation of Heterogeneous Causal Mediation Effects in a Hypertension Treatment Trial
by: Zhao, Yi, et al.
Published: (2025)
by: Zhao, Yi, et al.
Published: (2025)
Statistical Inference for Heterogeneous Treatment Effect with Right-censored Data from Synthesizing Randomized Clinical Trials and Real-world Data
by: Mao, Guangcai, et al.
Published: (2025)
by: Mao, Guangcai, et al.
Published: (2025)
A Precision Trial Case Study for Heterogeneous Treatment Effects in Obstructive Sleep Apnea
by: Maleyeff, Lara, et al.
Published: (2025)
by: Maleyeff, Lara, et al.
Published: (2025)
Heterogeneous Clinical Trial Outcomes via Multi-Output Gaussian Processes
by: Thomas, Owen, et al.
Published: (2024)
by: Thomas, Owen, et al.
Published: (2024)
Identifying Treatment Effect Heterogeneity with Bayesian Hierarchical Adjustable Random Partition in Adaptive Enrichment Trials
by: Zhao, Xianglin, et al.
Published: (2025)
by: Zhao, Xianglin, et al.
Published: (2025)
Consistency Assessment of Regional Treatment Effect for Multi-Regional Clinical Trials in the Presence of Covariate Shift
by: Qing, Kunhai, et al.
Published: (2026)
by: Qing, Kunhai, et al.
Published: (2026)
Regulatory Expectations for Bayesian Methods in Drug and Biologic Clinical Trials: A Practical Perspective on FDA's 2026 Draft Guidance
by: Ji, Yuan, et al.
Published: (2026)
by: Ji, Yuan, et al.
Published: (2026)
A Bayesian Treatment Selection Design for Phase II Randomised Cancer Clinical Trials
by: Komaki, Moka, et al.
Published: (2025)
by: Komaki, Moka, et al.
Published: (2025)
EASI Drugs in the Streets of Colombia: Modeling Heterogeneous and Endogenous Drug Preferences
by: Montoya-Blandón, Santiago, et al.
Published: (2025)
by: Montoya-Blandón, Santiago, et al.
Published: (2025)
Multi-fidelity Gaussian process regression for noisy outputs and non-nested experimental designs: a comparison between the recursive and non-recursive formulations
by: Baillie, Nils, et al.
Published: (2025)
by: Baillie, Nils, et al.
Published: (2025)
Study Duration Prediction for Clinical Trials with Time-to-Event Endpoints Using Mixture Distributions Accounting for Heterogeneous Population
by: Zhang, Hong, et al.
Published: (2023)
by: Zhang, Hong, et al.
Published: (2023)
Distribution-Based Sub-Population Selection (DSPS): A Method for in-Silico Reproduction of Clinical Trials Outcomes
by: Ganji, Mohammadreza, et al.
Published: (2024)
by: Ganji, Mohammadreza, et al.
Published: (2024)
Correcting for confounding in longitudinal experiments: positioning non-linear mixed effects modeling as implementation of standardization using latent conditional exchangeability
by: Bartels, Christian, et al.
Published: (2024)
by: Bartels, Christian, et al.
Published: (2024)
Considerations for Single-Arm Trials to Support Accelerated Approval of Oncology Drugs
by: Lu, Feinan, et al.
Published: (2024)
by: Lu, Feinan, et al.
Published: (2024)
Subgroup Identification and Individualized Treatment Policies: A Tutorial on the Hybrid Two-Stage Workflow
by: Xi, Nan Miles, et al.
Published: (2025)
by: Xi, Nan Miles, et al.
Published: (2025)
Use of Mobile Application for Improving Drug Compliance and Clinical Outcomes: A Randomized Controlled Trial
by: Pramod Kumar Mehta, et al.
Published: (2026)
by: Pramod Kumar Mehta, et al.
Published: (2026)
Comparing Methods of Expert Elicitation for Treatment Effect or Borrowing Parameters in Standard and Rare Disease Clinical Trials: A Systematic Mapping Study
by: Morgan, Laura M., et al.
Published: (2025)
by: Morgan, Laura M., et al.
Published: (2025)
Treatment Effect Heterogeneity and Importance Measures for Multivariate Continuous Treatments
by: Shin, Heejun, et al.
Published: (2024)
by: Shin, Heejun, et al.
Published: (2024)
Generalized Design of Basket Trials with P-value Combination Test
by: Zhou, Heng, et al.
Published: (2024)
by: Zhou, Heng, et al.
Published: (2024)
Learning Smooth Populations of Parameters with Trial Heterogeneity
by: Lee, JungHo, et al.
Published: (2025)
by: Lee, JungHo, et al.
Published: (2025)
Statistical Design and Rationale of the Biomarkers for Evaluating Spine Treatments (BEST) Trial
by: Sperger, John, et al.
Published: (2025)
by: Sperger, John, et al.
Published: (2025)
A Causal Machine Learning Framework for Treatment Personalization in Clinical Trials: Application to Ulcerative Colitis
by: Minoccheri, Cristian, et al.
Published: (2026)
by: Minoccheri, Cristian, et al.
Published: (2026)
Assessing Vaccine Effectiveness in Observational Studies via Nested Trial Emulation
by: DeMonte, Justin B., et al.
Published: (2024)
by: DeMonte, Justin B., et al.
Published: (2024)
Efficiency of nonparametric superiority tests based on restricted mean survival time versus the log-rank test under proportional hazards
by: Magirr, Dominic, et al.
Published: (2024)
by: Magirr, Dominic, et al.
Published: (2024)
Estimating Treatment Effect Heterogeneity in Psychiatry: A Review and Tutorial with Causal Forests
by: Sverdrup, Erik, et al.
Published: (2024)
by: Sverdrup, Erik, et al.
Published: (2024)
Similar Items
-
WATCH: A Workflow to Assess Treatment Effect Heterogeneity in Drug Development for Clinical Trial Sponsors
by: Konstantinos Sechidis, et al.
Published: (2024) -
Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity
by: Sechidis, Konstantinos, et al.
Published: (2025) -
A Workflow for Evaluating Regional Treatment Effect Heterogeneity in Multi-Regional Clinical Trials
by: Zhang, Cong, et al.
Published: (2026) -
Comparing methods to assess treatment effect heterogeneity in general parametric regression models
by: Chen, Yao, et al.
Published: (2025) -
Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity
by: Konstantinos Sechidis, et al.
Published: (2025)