Variable Selection in Ultra-high Dimensional Feature Space for the Cox Model with Interval-Censored Data

Fuente: arXiv
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Autori principali: Pak, Daewoo, Zhang, Jianrui, Wu, Di, Weng, Haolei, Li, Chenxi
Natura: Preprint
Pubblicazione: 2024
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author Pak, Daewoo
Zhang, Jianrui
Wu, Di
Weng, Haolei
Li, Chenxi
author_facet Pak, Daewoo
Zhang, Jianrui
Wu, Di
Weng, Haolei
Li, Chenxi
contents We develop a set of variable selection methods for the Cox model under interval censoring, in the ultra-high dimensional setting where the dimensionality can grow exponentially with the sample size. The methods select covariates via a penalized nonparametric maximum likelihood estimation with some popular penalty functions, including lasso, adaptive lasso, SCAD, and MCP. We prove that our penalized variable selection methods with folded concave penalties or adaptive lasso penalty enjoy the oracle property. Extensive numerical experiments show that the proposed methods have satisfactory empirical performance under various scenarios. The utility of the methods is illustrated through an application to a genome-wide association study of age to early childhood caries.
format Preprint
id arxiv_https___arxiv_org_abs_2405_01275
institution arXiv
publishDate 2024
record_format arxiv
spellingShingle Variable Selection in Ultra-high Dimensional Feature Space for the Cox Model with Interval-Censored Data
Pak, Daewoo
Zhang, Jianrui
Wu, Di
Weng, Haolei
Li, Chenxi
Methodology
We develop a set of variable selection methods for the Cox model under interval censoring, in the ultra-high dimensional setting where the dimensionality can grow exponentially with the sample size. The methods select covariates via a penalized nonparametric maximum likelihood estimation with some popular penalty functions, including lasso, adaptive lasso, SCAD, and MCP. We prove that our penalized variable selection methods with folded concave penalties or adaptive lasso penalty enjoy the oracle property. Extensive numerical experiments show that the proposed methods have satisfactory empirical performance under various scenarios. The utility of the methods is illustrated through an application to a genome-wide association study of age to early childhood caries.
title Variable Selection in Ultra-high Dimensional Feature Space for the Cox Model with Interval-Censored Data
topic Methodology
url https://arxiv.org/abs/2405.01275