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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2405.02756 |
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| _version_ | 1866910696721088512 |
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| author | Fan, Keming Chen, Wei-Chen Pinge, Sumukh Wong, H. -S. Philip Rosing, Tajana |
| author_facet | Fan, Keming Chen, Wei-Chen Pinge, Sumukh Wong, H. -S. Philip Rosing, Tajana |
| contents | Open Modification Search (OMS) is a promising algorithm for mass spectrometry analysis that enables the discovery of modified peptides. However, OMS encounters challenges as it exponentially extends the search scope. Existing OMS accelerators either have limited parallelism or struggle to scale effectively with growing data volumes. In this work, we introduce an OMS accelerator utilizing multi-level-cell (MLC) RRAM memory to enhance storage capacity by 3x. Through in-memory computing, we achieve up to 77x faster data processing with two to three orders of magnitude better energy efficiency. Testing was done on a fabricated MLC RRAM chip. We leverage hyperdimensional computing to tolerate up to 10% memory errors while delivering massive parallelism in hardware. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2405_02756 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Efficient Open Modification Spectral Library Searching in High-Dimensional Space with Multi-Level-Cell Memory Fan, Keming Chen, Wei-Chen Pinge, Sumukh Wong, H. -S. Philip Rosing, Tajana Hardware Architecture Open Modification Search (OMS) is a promising algorithm for mass spectrometry analysis that enables the discovery of modified peptides. However, OMS encounters challenges as it exponentially extends the search scope. Existing OMS accelerators either have limited parallelism or struggle to scale effectively with growing data volumes. In this work, we introduce an OMS accelerator utilizing multi-level-cell (MLC) RRAM memory to enhance storage capacity by 3x. Through in-memory computing, we achieve up to 77x faster data processing with two to three orders of magnitude better energy efficiency. Testing was done on a fabricated MLC RRAM chip. We leverage hyperdimensional computing to tolerate up to 10% memory errors while delivering massive parallelism in hardware. |
| title | Efficient Open Modification Spectral Library Searching in High-Dimensional Space with Multi-Level-Cell Memory |
| topic | Hardware Architecture |
| url | https://arxiv.org/abs/2405.02756 |