Alterations of electrocortical activity during hand movements induced by motor cortex glioma
Fuente:
arXiv
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| Materias: | |
| Acceso en línea: | |
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| _version_ | 1866929348980768768 |
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| author | Wu, Yihan Chang, Tao Chen, Siliang Niu, Xiaodong Li, Yu Fang, Yuan Yang, Lei Zong, Yixuan Yang, Yaoxin Li, Yuehua Wang, Mengsong Yang, Wen Wu, Yixuan Fu, Chen Fang, Xia Quan, Yuxin Peng, Xilin Sun, Qiang Van Hulle, Marc M. Liu, Yanhui Jiang, Ning Farina, Dario Yang, Yuan He, Jiayuan Mao, Qing |
| author_facet | Wu, Yihan Chang, Tao Chen, Siliang Niu, Xiaodong Li, Yu Fang, Yuan Yang, Lei Zong, Yixuan Yang, Yaoxin Li, Yuehua Wang, Mengsong Yang, Wen Wu, Yixuan Fu, Chen Fang, Xia Quan, Yuxin Peng, Xilin Sun, Qiang Van Hulle, Marc M. Liu, Yanhui Jiang, Ning Farina, Dario Yang, Yuan He, Jiayuan Mao, Qing |
| contents | Glioma cells can reshape functional neuronal networks by hijacking neuronal synapses, leading to partial or complete neurological dysfunction. These mechanisms have been previously explored for language functions. However, the impact of glioma on sensorimotor functions is still unknown. Therefore, we recruited a control group of patients with unaffected motor cortex and a group of patients with glioma-infiltrated motor cortex, and recorded high-density electrocortical signals during finger movement tasks. The results showed that glioma suppresses task-related synchronization in the high-gamma band and reduces the power across all frequency bands. The resulting atypical motor information transmission model with discrete signaling pathways and delayed responses disrupts the stability of neuronal encoding patterns for finger movement kinematics across various temporal-spatial scales. These findings demonstrate that gliomas functionally invade neural circuits within the motor cortex. This result advances our understanding of motor function processing in chronic disease states, which is important to advance the surgical strategies and neurorehabilitation approaches for patients with malignant gliomas. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2405_12144 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Alterations of electrocortical activity during hand movements induced by motor cortex glioma Wu, Yihan Chang, Tao Chen, Siliang Niu, Xiaodong Li, Yu Fang, Yuan Yang, Lei Zong, Yixuan Yang, Yaoxin Li, Yuehua Wang, Mengsong Yang, Wen Wu, Yixuan Fu, Chen Fang, Xia Quan, Yuxin Peng, Xilin Sun, Qiang Van Hulle, Marc M. Liu, Yanhui Jiang, Ning Farina, Dario Yang, Yuan He, Jiayuan Mao, Qing Neurons and Cognition Glioma cells can reshape functional neuronal networks by hijacking neuronal synapses, leading to partial or complete neurological dysfunction. These mechanisms have been previously explored for language functions. However, the impact of glioma on sensorimotor functions is still unknown. Therefore, we recruited a control group of patients with unaffected motor cortex and a group of patients with glioma-infiltrated motor cortex, and recorded high-density electrocortical signals during finger movement tasks. The results showed that glioma suppresses task-related synchronization in the high-gamma band and reduces the power across all frequency bands. The resulting atypical motor information transmission model with discrete signaling pathways and delayed responses disrupts the stability of neuronal encoding patterns for finger movement kinematics across various temporal-spatial scales. These findings demonstrate that gliomas functionally invade neural circuits within the motor cortex. This result advances our understanding of motor function processing in chronic disease states, which is important to advance the surgical strategies and neurorehabilitation approaches for patients with malignant gliomas. |
| title | Alterations of electrocortical activity during hand movements induced by motor cortex glioma |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2405.12144 |