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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| Soggetti: | |
| Accesso online: | https://arxiv.org/abs/2405.12966 |
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| _version_ | 1866917672511340544 |
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| author | Liu, Jingjing Wright, Alex R. Hynynen, Kullervo Goertz, David E. |
| author_facet | Liu, Jingjing Wright, Alex R. Hynynen, Kullervo Goertz, David E. |
| contents | Thrombotic and chronic occlusions of large blood vessels are a major cause of mortality and morbidity, and so there is a need for improved treatments in many clinical circumstances. Endovascular ultrasound approaches have been shown to hold considerable potential to treat large vessel thrombotic occlusions. Here, we report the development of a novel forward-looking therapeutic ultrasound catheter approach. The design concept centers on the use of a radially polarized hollow cylindrical transducer situated at the distal tip. This approach enables a compact configuration where the central lumen can accommodate a guidewire during navigation as well as provide a route to release cavitation seeds and therapeutic agents adjacent to the site of occlusion. PZT-5H transducers with outer/inner diameters of 1.35/0.73 mm were evaluated using simulations and experiments for their capacity to project forward-looking ultrasound. A length of 2.5 mm operating in the 3rd harmonic of the length mode resonance (1.85 MHz) was selected. Catheters (1.55 mm outer diameter) were designed and fabricated with a liner, outer jacket, and braiding, where the transducers were incorporated with air-backing and a front-face matching layer. Forward-looking pressures of 2.5 MPa (peak negative) at 0.5 mm were achieved. Proof of principle vessel phantom experiments were performed demonstrating the ability to eject microbubbles in proximity to an occlusion and stimulate inertial cavitation. This approach holds potential for treating thrombotic and chronic total occlusions. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2405_12966 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | A novel forward-looking ultrasound catheter for treating vascular occlusions Liu, Jingjing Wright, Alex R. Hynynen, Kullervo Goertz, David E. Medical Physics Thrombotic and chronic occlusions of large blood vessels are a major cause of mortality and morbidity, and so there is a need for improved treatments in many clinical circumstances. Endovascular ultrasound approaches have been shown to hold considerable potential to treat large vessel thrombotic occlusions. Here, we report the development of a novel forward-looking therapeutic ultrasound catheter approach. The design concept centers on the use of a radially polarized hollow cylindrical transducer situated at the distal tip. This approach enables a compact configuration where the central lumen can accommodate a guidewire during navigation as well as provide a route to release cavitation seeds and therapeutic agents adjacent to the site of occlusion. PZT-5H transducers with outer/inner diameters of 1.35/0.73 mm were evaluated using simulations and experiments for their capacity to project forward-looking ultrasound. A length of 2.5 mm operating in the 3rd harmonic of the length mode resonance (1.85 MHz) was selected. Catheters (1.55 mm outer diameter) were designed and fabricated with a liner, outer jacket, and braiding, where the transducers were incorporated with air-backing and a front-face matching layer. Forward-looking pressures of 2.5 MPa (peak negative) at 0.5 mm were achieved. Proof of principle vessel phantom experiments were performed demonstrating the ability to eject microbubbles in proximity to an occlusion and stimulate inertial cavitation. This approach holds potential for treating thrombotic and chronic total occlusions. |
| title | A novel forward-looking ultrasound catheter for treating vascular occlusions |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2405.12966 |