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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2405.15764 |
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| _version_ | 1866910458800242688 |
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| author | Gong, Li Wright, Alex R. Hynynen, Kullervo Goertz, David E. |
| author_facet | Gong, Li Wright, Alex R. Hynynen, Kullervo Goertz, David E. |
| contents | To address existing challenges with intravascular mechanical thrombectomy devices, a novel ultrasound-enhanced aspiration approach is being developed to mechanically degrade clots using cavitation. This method employs standing waves within a mm-scale hollow cylindrical transducer to generate high pressures sufficient to perform histotripsy on clots situated within the transducer lumen and generate substantial lesions. The objective of this study is to assess the feasibility of self-sensing cavitation detection by analyzing voltage signals across the transducer during treatment pulses. External ultrasound imaging of the transducer lumen validated cavitation detection. Impedance was also altered by the presence of clot material within the lumen. Experiments varying the driving voltage in water-filled lumens demonstrated changes in the relative amplitudes of the envelopes of the pulse body and ringdown portions of the voltage signals above the cavitation threshold, as well as changes in the spectral domain. In particular both broadband and ultraharmonic signals showed an increase in amplitude above the cavitation threshold. Similar temporal and spectral voltage signal changes in the presence of cavitation were also observed when treating clots within the lumen. This work demonstrates a highly sensitive method for detecting cavitation within the lumen, enabling monitoring with readily acquired signals without additional sensors in the catheter configuration. These findings hold significant potential for improving the efficacy of ultrasound-enhanced aspiration thrombectomy procedures. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2405_15764 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Self-sensing with hollow cylindrical transducers for histotripsy enhanced aspiration mechanical thrombectomy applications Gong, Li Wright, Alex R. Hynynen, Kullervo Goertz, David E. Medical Physics To address existing challenges with intravascular mechanical thrombectomy devices, a novel ultrasound-enhanced aspiration approach is being developed to mechanically degrade clots using cavitation. This method employs standing waves within a mm-scale hollow cylindrical transducer to generate high pressures sufficient to perform histotripsy on clots situated within the transducer lumen and generate substantial lesions. The objective of this study is to assess the feasibility of self-sensing cavitation detection by analyzing voltage signals across the transducer during treatment pulses. External ultrasound imaging of the transducer lumen validated cavitation detection. Impedance was also altered by the presence of clot material within the lumen. Experiments varying the driving voltage in water-filled lumens demonstrated changes in the relative amplitudes of the envelopes of the pulse body and ringdown portions of the voltage signals above the cavitation threshold, as well as changes in the spectral domain. In particular both broadband and ultraharmonic signals showed an increase in amplitude above the cavitation threshold. Similar temporal and spectral voltage signal changes in the presence of cavitation were also observed when treating clots within the lumen. This work demonstrates a highly sensitive method for detecting cavitation within the lumen, enabling monitoring with readily acquired signals without additional sensors in the catheter configuration. These findings hold significant potential for improving the efficacy of ultrasound-enhanced aspiration thrombectomy procedures. |
| title | Self-sensing with hollow cylindrical transducers for histotripsy enhanced aspiration mechanical thrombectomy applications |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2405.15764 |