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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2405.18605 |
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| _version_ | 1866912873957031936 |
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| author | Nguyen, Mai H. Likhite, Shibani Tang, Jiawei Mahendran, Darshini McInnes, Bridget T. |
| author_facet | Nguyen, Mai H. Likhite, Shibani Tang, Jiawei Mahendran, Darshini McInnes, Bridget T. |
| contents | The extraction of chemical-gene relations plays a pivotal role in understanding the intricate interactions between chemical compounds and genes, with significant implications for drug discovery, disease understanding, and biomedical research. This paper presents a data set created by merging the ChemProt and DrugProt datasets to augment sample counts and improve model accuracy. We evaluate the merged dataset using two state of the art relationship extraction algorithms: Bidirectional Encoder Representations from Transformers (BERT) specifically BioBERT, and Graph Convolutional Networks (GCNs) combined with BioBERT. While BioBERT excels at capturing local contexts, it may benefit from incorporating global information essential for understanding chemical-gene interactions. This can be achieved by integrating GCNs with BioBERT to harness both global and local context. Our results show that by integrating the ChemProt and DrugProt datasets, we demonstrated significant improvements in model performance, particularly in CPR groups shared between the datasets. Incorporating the global context using GCN can help increase the overall precision and recall in some of the CPR groups over using just BioBERT. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2405_18605 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Merged ChemProt-DrugProt for Relation Extraction from Biomedical Literature Nguyen, Mai H. Likhite, Shibani Tang, Jiawei Mahendran, Darshini McInnes, Bridget T. Computation and Language Artificial Intelligence Information Retrieval Molecular Networks The extraction of chemical-gene relations plays a pivotal role in understanding the intricate interactions between chemical compounds and genes, with significant implications for drug discovery, disease understanding, and biomedical research. This paper presents a data set created by merging the ChemProt and DrugProt datasets to augment sample counts and improve model accuracy. We evaluate the merged dataset using two state of the art relationship extraction algorithms: Bidirectional Encoder Representations from Transformers (BERT) specifically BioBERT, and Graph Convolutional Networks (GCNs) combined with BioBERT. While BioBERT excels at capturing local contexts, it may benefit from incorporating global information essential for understanding chemical-gene interactions. This can be achieved by integrating GCNs with BioBERT to harness both global and local context. Our results show that by integrating the ChemProt and DrugProt datasets, we demonstrated significant improvements in model performance, particularly in CPR groups shared between the datasets. Incorporating the global context using GCN can help increase the overall precision and recall in some of the CPR groups over using just BioBERT. |
| title | Merged ChemProt-DrugProt for Relation Extraction from Biomedical Literature |
| topic | Computation and Language Artificial Intelligence Information Retrieval Molecular Networks |
| url | https://arxiv.org/abs/2405.18605 |