Activity-driven polymer knotting for macromolecular topology engineering
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arXiv
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| Autori principali: | , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| _version_ | 1866916511812157440 |
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| author | Li, Jia-Xiang Wu, Song Hao, Li-Li Lei, Qun-Li Ma, Yu-Qiang |
| author_facet | Li, Jia-Xiang Wu, Song Hao, Li-Li Lei, Qun-Li Ma, Yu-Qiang |
| contents | Macromolecules can gain special properties by adopting knotted conformations, but engineering knotted macromolecules is a challenging task. Here we surprisingly observed that knotting can be very effectively produced in active polymers. When one end of an actively reptative polymer is anchored, it can undergo continual self-knotting as a result of intermittent giant conformation fluctuations and the outward reptative motion. Once a knot is formed, it migrates to the anchored point due to a non-equilibrium ratchet effect. Moreover, when the active polymer is grafted on the end of a passive polymer, it can function as a self-propelling soft needle to either transfer its own knots to the passive polymer or directly braid knots on the passive polymer. We further show that these active needles can create inter-molecular bridging knots between two passive polymers. Our finding highlights the non-equilibrium effects in modifying the dynamic pathways of polymer systems, which have potential applications in macromolecular topology engineering, e.g., manipulating topological states of proteins and nucleic acids, as well as macromolecular braiding. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2405_20938 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Activity-driven polymer knotting for macromolecular topology engineering Li, Jia-Xiang Wu, Song Hao, Li-Li Lei, Qun-Li Ma, Yu-Qiang Soft Condensed Matter Macromolecules can gain special properties by adopting knotted conformations, but engineering knotted macromolecules is a challenging task. Here we surprisingly observed that knotting can be very effectively produced in active polymers. When one end of an actively reptative polymer is anchored, it can undergo continual self-knotting as a result of intermittent giant conformation fluctuations and the outward reptative motion. Once a knot is formed, it migrates to the anchored point due to a non-equilibrium ratchet effect. Moreover, when the active polymer is grafted on the end of a passive polymer, it can function as a self-propelling soft needle to either transfer its own knots to the passive polymer or directly braid knots on the passive polymer. We further show that these active needles can create inter-molecular bridging knots between two passive polymers. Our finding highlights the non-equilibrium effects in modifying the dynamic pathways of polymer systems, which have potential applications in macromolecular topology engineering, e.g., manipulating topological states of proteins and nucleic acids, as well as macromolecular braiding. |
| title | Activity-driven polymer knotting for macromolecular topology engineering |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2405.20938 |