Diamond molecular balance: Revolutionizing high-resolution mass spectrometry from MDa to TDa at room temperature
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arXiv
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866909267154436096 |
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| author | Lee, Donggeun Jeon, Seung-Woo Yi, Chang-Hwan Kim, Yang-Hee Choi, Yeeun Lee, Sang-Hun Cha, Jinwoong Shim, Seung-Bo Suh, Junho Kim, Il-Young Kang, Dongyeon Daniel Jung, Hojoong Jeong, Cherlhyun Ahn, Jae-pyoung Park, Hee Chul Han, Sang-Wook Kim, Chulki |
| author_facet | Lee, Donggeun Jeon, Seung-Woo Yi, Chang-Hwan Kim, Yang-Hee Choi, Yeeun Lee, Sang-Hun Cha, Jinwoong Shim, Seung-Bo Suh, Junho Kim, Il-Young Kang, Dongyeon Daniel Jung, Hojoong Jeong, Cherlhyun Ahn, Jae-pyoung Park, Hee Chul Han, Sang-Wook Kim, Chulki |
| contents | The significance of mass spectrometry lies in its unparalleled ability to accurately identify and quantify molecules in complex samples, providing invaluable insights into molecular structures and interactions. Here, we leverage diamond nanostructures as highly sensitive mass sensors by utilizing a self-excitation mechanism under an electron beam in a conventional scanning electron microscope (SEM). The diamond molecular balance (DMB) exhibits an exceptional mass resolution of 0.36 MDa, based on its outstanding mechanical quality factor and frequency stability, along with an extensive dynamic range from MDa to TDa. This positions the DMB at the forefront of molecular balances operating at room temperature. Notably, the DMB demonstrates its ability to measure the mass of a single bacteriophage T4 by precisely locating the analyte on the device. These findings highlight the groundbreaking potential of the DMB as a revolutionary tool for mass spectrometry at room temperature. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2406_01963 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Diamond molecular balance: Revolutionizing high-resolution mass spectrometry from MDa to TDa at room temperature Lee, Donggeun Jeon, Seung-Woo Yi, Chang-Hwan Kim, Yang-Hee Choi, Yeeun Lee, Sang-Hun Cha, Jinwoong Shim, Seung-Bo Suh, Junho Kim, Il-Young Kang, Dongyeon Daniel Jung, Hojoong Jeong, Cherlhyun Ahn, Jae-pyoung Park, Hee Chul Han, Sang-Wook Kim, Chulki Mesoscale and Nanoscale Physics Applied Physics The significance of mass spectrometry lies in its unparalleled ability to accurately identify and quantify molecules in complex samples, providing invaluable insights into molecular structures and interactions. Here, we leverage diamond nanostructures as highly sensitive mass sensors by utilizing a self-excitation mechanism under an electron beam in a conventional scanning electron microscope (SEM). The diamond molecular balance (DMB) exhibits an exceptional mass resolution of 0.36 MDa, based on its outstanding mechanical quality factor and frequency stability, along with an extensive dynamic range from MDa to TDa. This positions the DMB at the forefront of molecular balances operating at room temperature. Notably, the DMB demonstrates its ability to measure the mass of a single bacteriophage T4 by precisely locating the analyte on the device. These findings highlight the groundbreaking potential of the DMB as a revolutionary tool for mass spectrometry at room temperature. |
| title | Diamond molecular balance: Revolutionizing high-resolution mass spectrometry from MDa to TDa at room temperature |
| topic | Mesoscale and Nanoscale Physics Applied Physics |
| url | https://arxiv.org/abs/2406.01963 |