Prediction-powered Generalization of Causal Inferences

Fuente: arXiv
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Autores principales: Demirel, Ilker, Alaa, Ahmed, Philippakis, Anthony, Sontag, David
Formato: Preprint
Publicado: 2024
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author Demirel, Ilker
Alaa, Ahmed
Philippakis, Anthony
Sontag, David
author_facet Demirel, Ilker
Alaa, Ahmed
Philippakis, Anthony
Sontag, David
contents Causal inferences from a randomized controlled trial (RCT) may not pertain to a target population where some effect modifiers have a different distribution. Prior work studies generalizing the results of a trial to a target population with no outcome but covariate data available. We show how the limited size of trials makes generalization a statistically infeasible task, as it requires estimating complex nuisance functions. We develop generalization algorithms that supplement the trial data with a prediction model learned from an additional observational study (OS), without making any assumptions on the OS. We theoretically and empirically show that our methods facilitate better generalization when the OS is high-quality, and remain robust when it is not, and e.g., have unmeasured confounding.
format Preprint
id arxiv_https___arxiv_org_abs_2406_02873
institution arXiv
publishDate 2024
record_format arxiv
spellingShingle Prediction-powered Generalization of Causal Inferences
Demirel, Ilker
Alaa, Ahmed
Philippakis, Anthony
Sontag, David
Machine Learning
Causal inferences from a randomized controlled trial (RCT) may not pertain to a target population where some effect modifiers have a different distribution. Prior work studies generalizing the results of a trial to a target population with no outcome but covariate data available. We show how the limited size of trials makes generalization a statistically infeasible task, as it requires estimating complex nuisance functions. We develop generalization algorithms that supplement the trial data with a prediction model learned from an additional observational study (OS), without making any assumptions on the OS. We theoretically and empirically show that our methods facilitate better generalization when the OS is high-quality, and remain robust when it is not, and e.g., have unmeasured confounding.
title Prediction-powered Generalization of Causal Inferences
topic Machine Learning
url https://arxiv.org/abs/2406.02873