The Chorioallantoic Membrane Model: A 3D in vivo Testbed for Design and Analysis of MC Systems
Fuente:
arXiv
Salvato in:
| Autori principali: | , , , , , , , |
|---|---|
| Natura: | Preprint |
| Pubblicazione: |
2024
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866917694059577344 |
|---|---|
| author | Schäfer, Maximilian Ettner-Sitter, Andreas Brand, Lukas Lotter, Sebastian Vakilipoor, Fardad Aung, Thiha Haerteis, Silke Schober, Robert |
| author_facet | Schäfer, Maximilian Ettner-Sitter, Andreas Brand, Lukas Lotter, Sebastian Vakilipoor, Fardad Aung, Thiha Haerteis, Silke Schober, Robert |
| contents | Molecular Communications (MC) research is increasingly focused on applications within the human body, such as health monitoring and drug delivery. These applications require testing in realistic and living environments. Thus, advancing experimental MC research to the next level requires the development of in vivo experimental testbeds. In this paper, we introduce the Chorioallantoic Membrane ( CAM ) model as a versatile 3D in vivo MC testbed. The CAM is a highly vascularized membrane formed in fertilized chicken eggs and has gained significance in various research fields, including bioengineering, cancer research, and drug development. Its versatility, reproducibility, and realistic biological properties make the CAM model perfectly suited for next-generation MC testbeds, facilitating the transition from proof-of-concept systems to practical applications. We provide a comprehensive introduction to the CAM model, its properties, and its applications in practical research. Additionally, we present a characterization of the CAM model as an MC system. As a preliminary experimental study, we investigate the distribution of fluorescent molecules in the closed-loop vascular system of the CAM model. We also derive an approximate analytical model for the propagation of molecules in closed-loop systems, and show that the proposed model is able to approximate molecule propagation in the CAM model. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2406_09875 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | The Chorioallantoic Membrane Model: A 3D in vivo Testbed for Design and Analysis of MC Systems Schäfer, Maximilian Ettner-Sitter, Andreas Brand, Lukas Lotter, Sebastian Vakilipoor, Fardad Aung, Thiha Haerteis, Silke Schober, Robert Emerging Technologies Molecular Communications (MC) research is increasingly focused on applications within the human body, such as health monitoring and drug delivery. These applications require testing in realistic and living environments. Thus, advancing experimental MC research to the next level requires the development of in vivo experimental testbeds. In this paper, we introduce the Chorioallantoic Membrane ( CAM ) model as a versatile 3D in vivo MC testbed. The CAM is a highly vascularized membrane formed in fertilized chicken eggs and has gained significance in various research fields, including bioengineering, cancer research, and drug development. Its versatility, reproducibility, and realistic biological properties make the CAM model perfectly suited for next-generation MC testbeds, facilitating the transition from proof-of-concept systems to practical applications. We provide a comprehensive introduction to the CAM model, its properties, and its applications in practical research. Additionally, we present a characterization of the CAM model as an MC system. As a preliminary experimental study, we investigate the distribution of fluorescent molecules in the closed-loop vascular system of the CAM model. We also derive an approximate analytical model for the propagation of molecules in closed-loop systems, and show that the proposed model is able to approximate molecule propagation in the CAM model. |
| title | The Chorioallantoic Membrane Model: A 3D in vivo Testbed for Design and Analysis of MC Systems |
| topic | Emerging Technologies |
| url | https://arxiv.org/abs/2406.09875 |