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Main Authors: Shaik, Nagur Shareef, Cherukuri, Teja Krishna, Calhoun, Vince, Ye, Dong Hye
Format: Preprint
Published: 2024
Subjects:
Online Access:https://arxiv.org/abs/2406.12683
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author Shaik, Nagur Shareef
Cherukuri, Teja Krishna
Calhoun, Vince
Ye, Dong Hye
author_facet Shaik, Nagur Shareef
Cherukuri, Teja Krishna
Calhoun, Vince
Ye, Dong Hye
contents Schizophrenia is a debilitating, chronic mental disorder that significantly impacts an individual's cognitive abilities, behavior, and social interactions. It is characterized by subtle morphological changes in the brain, particularly in the gray matter. These changes are often imperceptible through manual observation, demanding an automated approach to diagnosis. This study introduces a deep learning methodology for the classification of individuals with Schizophrenia. We achieve this by implementing a diversified attention mechanism known as Spatial Sequence Attention (SSA) which is designed to extract and emphasize significant feature representations from structural MRI (sMRI). Initially, we employ the transfer learning paradigm by leveraging pre-trained DenseNet to extract initial feature maps from the final convolutional block which contains morphological alterations associated with Schizophrenia. These features are further processed by the proposed SSA to capture and emphasize intricate spatial interactions and relationships across volumes within the brain. Our experimental studies conducted on a clinical dataset have revealed that the proposed attention mechanism outperforms the existing Squeeze & Excitation Network for Schizophrenia classification.
format Preprint
id arxiv_https___arxiv_org_abs_2406_12683
institution arXiv
publishDate 2024
record_format arxiv
spellingShingle Spatial Sequence Attention Network for Schizophrenia Classification from Structural Brain MR Images
Shaik, Nagur Shareef
Cherukuri, Teja Krishna
Calhoun, Vince
Ye, Dong Hye
Computer Vision and Pattern Recognition
Machine Learning
Schizophrenia is a debilitating, chronic mental disorder that significantly impacts an individual's cognitive abilities, behavior, and social interactions. It is characterized by subtle morphological changes in the brain, particularly in the gray matter. These changes are often imperceptible through manual observation, demanding an automated approach to diagnosis. This study introduces a deep learning methodology for the classification of individuals with Schizophrenia. We achieve this by implementing a diversified attention mechanism known as Spatial Sequence Attention (SSA) which is designed to extract and emphasize significant feature representations from structural MRI (sMRI). Initially, we employ the transfer learning paradigm by leveraging pre-trained DenseNet to extract initial feature maps from the final convolutional block which contains morphological alterations associated with Schizophrenia. These features are further processed by the proposed SSA to capture and emphasize intricate spatial interactions and relationships across volumes within the brain. Our experimental studies conducted on a clinical dataset have revealed that the proposed attention mechanism outperforms the existing Squeeze & Excitation Network for Schizophrenia classification.
title Spatial Sequence Attention Network for Schizophrenia Classification from Structural Brain MR Images
topic Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2406.12683