Applications of interpretable deep learning in neuroimaging: a comprehensive review

Fuente: arXiv
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Autores principales: Munroe, Lindsay, da Silva, Mariana, Heidari, Faezeh, Grigorescu, Irina, Dahan, Simon, Robinson, Emma C., Deprez, Maria, So, Po-Wah
Formato: Preprint
Publicado: 2024
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author Munroe, Lindsay
da Silva, Mariana
Heidari, Faezeh
Grigorescu, Irina
Dahan, Simon
Robinson, Emma C.
Deprez, Maria
So, Po-Wah
author_facet Munroe, Lindsay
da Silva, Mariana
Heidari, Faezeh
Grigorescu, Irina
Dahan, Simon
Robinson, Emma C.
Deprez, Maria
So, Po-Wah
contents Clinical adoption of deep learning models has been hindered, in part, because the black-box nature of neural networks leads to concerns regarding their trustworthiness and reliability. These concerns are particularly relevant in the field of neuroimaging due to the complex brain phenotypes and inter-subject heterogeneity often encountered. The challenge can be addressed by interpretable deep learning (iDL) methods that enable the visualisation and interpretation of the inner workings of deep learning models. This study systematically reviewed the literature on neuroimaging applications of iDL methods and critically analysed how iDL explanation properties were evaluated. Seventy-five studies were included, and ten categories of iDL methods were identified. We also reviewed five properties of iDL explanations that were analysed in the included studies: biological validity, robustness, continuity, selectivity, and downstream task performance. We found that the most popular iDL approaches used in the literature may be sub-optimal for neuroimaging data, and we discussed possible future directions for the field.
format Preprint
id arxiv_https___arxiv_org_abs_2406_17792
institution arXiv
publishDate 2024
record_format arxiv
spellingShingle Applications of interpretable deep learning in neuroimaging: a comprehensive review
Munroe, Lindsay
da Silva, Mariana
Heidari, Faezeh
Grigorescu, Irina
Dahan, Simon
Robinson, Emma C.
Deprez, Maria
So, Po-Wah
Image and Video Processing
Computer Vision and Pattern Recognition
Neurons and Cognition
Clinical adoption of deep learning models has been hindered, in part, because the black-box nature of neural networks leads to concerns regarding their trustworthiness and reliability. These concerns are particularly relevant in the field of neuroimaging due to the complex brain phenotypes and inter-subject heterogeneity often encountered. The challenge can be addressed by interpretable deep learning (iDL) methods that enable the visualisation and interpretation of the inner workings of deep learning models. This study systematically reviewed the literature on neuroimaging applications of iDL methods and critically analysed how iDL explanation properties were evaluated. Seventy-five studies were included, and ten categories of iDL methods were identified. We also reviewed five properties of iDL explanations that were analysed in the included studies: biological validity, robustness, continuity, selectivity, and downstream task performance. We found that the most popular iDL approaches used in the literature may be sub-optimal for neuroimaging data, and we discussed possible future directions for the field.
title Applications of interpretable deep learning in neuroimaging: a comprehensive review
topic Image and Video Processing
Computer Vision and Pattern Recognition
Neurons and Cognition
url https://arxiv.org/abs/2406.17792