An LLM-based Knowledge Synthesis and Scientific Reasoning Framework for Biomedical Discovery
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| Main Authors: | , , , , , , , |
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| Format: | Preprint |
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2024
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| _version_ | 1866911934839783424 |
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| author | Wysocki, Oskar Wysocka, Magdalena Carvalho, Danilo Bogatu, Alex Teodor Gusicuma, Danilo Miranda Delmas, Maxime Unsworth, Harriet Freitas, Andre |
| author_facet | Wysocki, Oskar Wysocka, Magdalena Carvalho, Danilo Bogatu, Alex Teodor Gusicuma, Danilo Miranda Delmas, Maxime Unsworth, Harriet Freitas, Andre |
| contents | We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large Language Models (LLMs) to facilitate complex scientific reasoning across distributed evidence spaces, enhancing the capability for harmonizing and reasoning over heterogeneous data sources. Demonstrating its utility in cancer research, BioLunar leverages modular design, reusable data access and data analysis components, and a low-code user interface, enabling researchers of all programming levels to construct LLM-enabled scientific workflows. By facilitating automatic scientific discovery and inference from heterogeneous evidence, BioLunar exemplifies the potential of the integration between LLMs, specialised databases and biomedical tools to support expert-level knowledge synthesis and discovery. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2406_18626 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | An LLM-based Knowledge Synthesis and Scientific Reasoning Framework for Biomedical Discovery Wysocki, Oskar Wysocka, Magdalena Carvalho, Danilo Bogatu, Alex Teodor Gusicuma, Danilo Miranda Delmas, Maxime Unsworth, Harriet Freitas, Andre Quantitative Methods Artificial Intelligence Computation and Language We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large Language Models (LLMs) to facilitate complex scientific reasoning across distributed evidence spaces, enhancing the capability for harmonizing and reasoning over heterogeneous data sources. Demonstrating its utility in cancer research, BioLunar leverages modular design, reusable data access and data analysis components, and a low-code user interface, enabling researchers of all programming levels to construct LLM-enabled scientific workflows. By facilitating automatic scientific discovery and inference from heterogeneous evidence, BioLunar exemplifies the potential of the integration between LLMs, specialised databases and biomedical tools to support expert-level knowledge synthesis and discovery. |
| title | An LLM-based Knowledge Synthesis and Scientific Reasoning Framework for Biomedical Discovery |
| topic | Quantitative Methods Artificial Intelligence Computation and Language |
| url | https://arxiv.org/abs/2406.18626 |