Tuning the kinetics of intracellular transport
Fuente:
arXiv
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| Autori principali: | , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| Soggetti: | |
| Accesso online: | |
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| _version_ | 1866916337426628608 |
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| author | Suchitran, Ardra Manikandan, Sreekanth K |
| author_facet | Suchitran, Ardra Manikandan, Sreekanth K |
| contents | A variety of complex mechanisms, from chemical reaction pathways to active fluctuations, orchestrate molecular transport in intracellular environments. Despite significant recent progress in visualizing and probing these processes, little is known about how tunable the resulting dynamics is through external physical controllers. Here, we demonstrate that coarse-grained, reinforcement learning-based protocols can be developed to achieve highly localized and targeted cargo transport by kinesin motors on intracellular tracks. These protocols can be implemented in practice using optical tweezers, and their feasibility is showcased within experimentally relevant parameter regimes. Our results open new avenues for targeted control of intracellular transport processes, especially when opportunities for control are limited. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2407_18784 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Tuning the kinetics of intracellular transport Suchitran, Ardra Manikandan, Sreekanth K Statistical Mechanics A variety of complex mechanisms, from chemical reaction pathways to active fluctuations, orchestrate molecular transport in intracellular environments. Despite significant recent progress in visualizing and probing these processes, little is known about how tunable the resulting dynamics is through external physical controllers. Here, we demonstrate that coarse-grained, reinforcement learning-based protocols can be developed to achieve highly localized and targeted cargo transport by kinesin motors on intracellular tracks. These protocols can be implemented in practice using optical tweezers, and their feasibility is showcased within experimentally relevant parameter regimes. Our results open new avenues for targeted control of intracellular transport processes, especially when opportunities for control are limited. |
| title | Tuning the kinetics of intracellular transport |
| topic | Statistical Mechanics |
| url | https://arxiv.org/abs/2407.18784 |