Laser patterned diamond electrodes for adhesion and proliferation of human mesenchymal stem cells
Fuente:
arXiv
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Preprint |
| Veröffentlicht: |
2024
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866913450268033024 |
|---|---|
| author | Hashem, Hassan N. Al Abraham, Amanda N. Sharma, Deepak Chambers, Andre Moghaddar, Mehrnoosh Reeves, Chayla L. Srivastava, Sanjay K. Gelmi, Amy Ahnood, Arman |
| author_facet | Hashem, Hassan N. Al Abraham, Amanda N. Sharma, Deepak Chambers, Andre Moghaddar, Mehrnoosh Reeves, Chayla L. Srivastava, Sanjay K. Gelmi, Amy Ahnood, Arman |
| contents | The ability to form diamond electrodes on insulating polycrystalline diamond substrates using single-step laser patterning, and the use of the electrodes as a substrate that supports the adhesion and proliferation of human mesenchymal stem cells (hMSCs) is demonstrated. Laser induced graphitisation results in a conductive amorphous carbon surface, rich in oxygen and nitrogen terminations. This results in an electrode with a high specific capacitance of 182 uF/cm2, a wide water window of 3.25 V, and a low electrochemical impedance of 129 Ohms/cm2 at 1 kHz. The electrodes surface exhibited a good level of biocompatibility with hMSCs, supporting cell adhesion and proliferation. The cells cultured on the electrode displayed significant elongation and alignment along the direction of the laser patterned microgrooves. Because of its favourable electrochemical performance and biocompatibility, the laser-patterned diamond electrodes create a potential for a versatile platform in stem cell therapeutics. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2407_19582 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Laser patterned diamond electrodes for adhesion and proliferation of human mesenchymal stem cells Hashem, Hassan N. Al Abraham, Amanda N. Sharma, Deepak Chambers, Andre Moghaddar, Mehrnoosh Reeves, Chayla L. Srivastava, Sanjay K. Gelmi, Amy Ahnood, Arman Biological Physics The ability to form diamond electrodes on insulating polycrystalline diamond substrates using single-step laser patterning, and the use of the electrodes as a substrate that supports the adhesion and proliferation of human mesenchymal stem cells (hMSCs) is demonstrated. Laser induced graphitisation results in a conductive amorphous carbon surface, rich in oxygen and nitrogen terminations. This results in an electrode with a high specific capacitance of 182 uF/cm2, a wide water window of 3.25 V, and a low electrochemical impedance of 129 Ohms/cm2 at 1 kHz. The electrodes surface exhibited a good level of biocompatibility with hMSCs, supporting cell adhesion and proliferation. The cells cultured on the electrode displayed significant elongation and alignment along the direction of the laser patterned microgrooves. Because of its favourable electrochemical performance and biocompatibility, the laser-patterned diamond electrodes create a potential for a versatile platform in stem cell therapeutics. |
| title | Laser patterned diamond electrodes for adhesion and proliferation of human mesenchymal stem cells |
| topic | Biological Physics |
| url | https://arxiv.org/abs/2407.19582 |