Numerical and Lyapunov-Based Investigation of the Effect of Stenosis on Blood Transport Stability Using a Control-Theoretic PDE Model of Cardiovascular Flow
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arXiv
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| Formato: | Preprint |
| Publicado: |
2024
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| author | Singh, Shantanu Bekiaris-Liberis, Nikolaos |
| author_facet | Singh, Shantanu Bekiaris-Liberis, Nikolaos |
| contents | We perform various numerical tests to study the effect of (boundary) stenosis on blood flow stability, employing a detailed and accurate, second-order finite-volume scheme for numerically implementing a partial differential equation (PDE) model, using clinically realistic values for the artery's parameters and the blood inflow. The model consists of a baseline $2\times 2$ hetero-directional, nonlinear hyperbolic PDE system, in which, the stenosis' effect is described by a pressure drop at the outlet of an arterial segment considered. We then study the stability properties (observed in our numerical tests) of a reference trajectory, corresponding to a given time-varying inflow (e.g., a periodic trajectory with period equal to the time interval between two consecutive heartbeats) and stenosis severity, deriving the respective linearized system and constructing a Lyapunov functional. Due to the fact that the linearized system is time varying, with time-varying parameters depending on the reference trajectories themselves (that, in turn, depend in an implicit manner on the stenosis degree), which cannot be derived analytically, we verify the Lyapunov-based stability conditions obtained, numerically. Both the numerical tests and the Lyapunov-based stability analysis show that a reference trajectory is asymptotically stable with a decay rate that decreases as the stenosis severity deteriorates. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2408_01058 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Numerical and Lyapunov-Based Investigation of the Effect of Stenosis on Blood Transport Stability Using a Control-Theoretic PDE Model of Cardiovascular Flow Singh, Shantanu Bekiaris-Liberis, Nikolaos Numerical Analysis Systems and Control We perform various numerical tests to study the effect of (boundary) stenosis on blood flow stability, employing a detailed and accurate, second-order finite-volume scheme for numerically implementing a partial differential equation (PDE) model, using clinically realistic values for the artery's parameters and the blood inflow. The model consists of a baseline $2\times 2$ hetero-directional, nonlinear hyperbolic PDE system, in which, the stenosis' effect is described by a pressure drop at the outlet of an arterial segment considered. We then study the stability properties (observed in our numerical tests) of a reference trajectory, corresponding to a given time-varying inflow (e.g., a periodic trajectory with period equal to the time interval between two consecutive heartbeats) and stenosis severity, deriving the respective linearized system and constructing a Lyapunov functional. Due to the fact that the linearized system is time varying, with time-varying parameters depending on the reference trajectories themselves (that, in turn, depend in an implicit manner on the stenosis degree), which cannot be derived analytically, we verify the Lyapunov-based stability conditions obtained, numerically. Both the numerical tests and the Lyapunov-based stability analysis show that a reference trajectory is asymptotically stable with a decay rate that decreases as the stenosis severity deteriorates. |
| title | Numerical and Lyapunov-Based Investigation of the Effect of Stenosis on Blood Transport Stability Using a Control-Theoretic PDE Model of Cardiovascular Flow |
| topic | Numerical Analysis Systems and Control |
| url | https://arxiv.org/abs/2408.01058 |