Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure
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arXiv
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| Format: | Preprint |
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2024
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| _version_ | 1866910707939803136 |
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| author | Buonfiglio, Valentina Zagli, Niccolò Pertici, Irene Lombardi, Vincenzo Bianco, Pasquale Fanelli, Duccio |
| author_facet | Buonfiglio, Valentina Zagli, Niccolò Pertici, Irene Lombardi, Vincenzo Bianco, Pasquale Fanelli, Duccio |
| contents | A data fitting procedure is devised and thoroughly tested to provide self-consistent estimates of the relevant mechanokinetic parameters involved in a plausible scheme underpinning the output of an ensemble of myosin II molecular motors mimicking the muscle contraction. The method builds on a stochastic model accounting for the force exerted by the motor ensemble operated both in the low and high force-generating regimes corresponding to different temperature ranges. The proposed interpretative framework is successfully challenged against simulated data, meant to mimic the experimental output of a unidimensional synthetic nanomachine powered by pure muscle myosin isoforms. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2408_03676 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure Buonfiglio, Valentina Zagli, Niccolò Pertici, Irene Lombardi, Vincenzo Bianco, Pasquale Fanelli, Duccio Statistical Mechanics Soft Condensed Matter Biomolecules Populations and Evolution Tissues and Organs A data fitting procedure is devised and thoroughly tested to provide self-consistent estimates of the relevant mechanokinetic parameters involved in a plausible scheme underpinning the output of an ensemble of myosin II molecular motors mimicking the muscle contraction. The method builds on a stochastic model accounting for the force exerted by the motor ensemble operated both in the low and high force-generating regimes corresponding to different temperature ranges. The proposed interpretative framework is successfully challenged against simulated data, meant to mimic the experimental output of a unidimensional synthetic nanomachine powered by pure muscle myosin isoforms. |
| title | Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure |
| topic | Statistical Mechanics Soft Condensed Matter Biomolecules Populations and Evolution Tissues and Organs |
| url | https://arxiv.org/abs/2408.03676 |