Acto-myosin clusters as active units shaping living matter
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arXiv
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| Autori principali: | , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| _version_ | 1866916351350669312 |
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| author | Kruse, Karsten Berthoz, Rémi Barberi, Luca Reymann, Anne-Cécile Riveline, Daniel |
| author_facet | Kruse, Karsten Berthoz, Rémi Barberi, Luca Reymann, Anne-Cécile Riveline, Daniel |
| contents | Stress generation by the actin cytoskeleton shapes cells and tissues. Despite impressive progress in live imaging and quantitative physical descriptions of cytoskeletal network dynamics, the connection between processes at molecular scales and cell-scale spatio-temporal patterns is still unclear. Here we review studies reporting acto-myosin clusters of micrometer size and with lifetimes of several minutes in a large number of organisms ranging from fission yeast to humans. Such structures have also been found in reconstituted systems in vitro and in theoretical analysis of cytoskeletal dynamics. We propose that tracking these clusters can serve as a simple readout for characterising living matter. Spatio-temporal patterns of clusters could serve as determinants of morphogenetic processes that play similar roles in diverse organisms. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2408_05119 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Acto-myosin clusters as active units shaping living matter Kruse, Karsten Berthoz, Rémi Barberi, Luca Reymann, Anne-Cécile Riveline, Daniel Tissues and Organs Biomolecules Cell Behavior Molecular Networks Subcellular Processes Stress generation by the actin cytoskeleton shapes cells and tissues. Despite impressive progress in live imaging and quantitative physical descriptions of cytoskeletal network dynamics, the connection between processes at molecular scales and cell-scale spatio-temporal patterns is still unclear. Here we review studies reporting acto-myosin clusters of micrometer size and with lifetimes of several minutes in a large number of organisms ranging from fission yeast to humans. Such structures have also been found in reconstituted systems in vitro and in theoretical analysis of cytoskeletal dynamics. We propose that tracking these clusters can serve as a simple readout for characterising living matter. Spatio-temporal patterns of clusters could serve as determinants of morphogenetic processes that play similar roles in diverse organisms. |
| title | Acto-myosin clusters as active units shaping living matter |
| topic | Tissues and Organs Biomolecules Cell Behavior Molecular Networks Subcellular Processes |
| url | https://arxiv.org/abs/2408.05119 |