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| Main Authors: | , , |
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| Format: | Preprint |
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2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2408.09171 |
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| _version_ | 1866908456318926848 |
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| author | Cronin, Leroy Pagel, Sebastian Sharma, Abhishek |
| author_facet | Cronin, Leroy Pagel, Sebastian Sharma, Abhishek |
| contents | Chemputation reframes synthesis as the programmable execution of reaction code on a universally re-configurable hardware graph. Here we prove that a chemputer equipped with a finite, but extensible, set of reagents, catalysts and process conditions, together with a chempiler that maps reaction graphs onto hardware, is universal: it can generate any stable, isolable molecule in finite time and in analytically detectable quantity, provided real-time error correction keeps the per-step fidelity above the threshold set by the molecule's assembly index. The proof is constructed by casting the platform as a Chemical Synthesis Turing Machine (CSTM). The CSTM formalism supplies (i) an eight-tuple state definition that unifies reagents, process variables (including catalysts) and tape operations; (ii) the Universal Chemputation Principle; and (iii) a dynamic-error-correction routine ensuring fault tolerant execution. Linking this framework to assembly theory strengthens the definition of a molecule by demanding practical synthesizability and error correction becomes a prerequisite for universality. We validate the abstraction against >100 \c{hi}DL programs executed on a modular chemputer rigs spanning single step to multi-step routes. Mapping each procedure onto CSTM shows that the cumulative number of unit operations grows linearly with synthetic depth. Together, these results elevate chemical synthesis to the status of a general computation: algorithms written in \c{hi}DL are compiled to hardware, executed with closed-loop correction, and produce verifiable molecular outputs. By formalising chemistry in this way, the chemputer offers a path to shareable, executable chemical code, interoperable hardware ecosystems, and ultimately a searchable, provable atlas of chemical space. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2408_09171 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Chemputer and Chemputation -- A Universal Chemical Compound Synthesis Machine Cronin, Leroy Pagel, Sebastian Sharma, Abhishek Emerging Technologies Chemical Physics Chemputation reframes synthesis as the programmable execution of reaction code on a universally re-configurable hardware graph. Here we prove that a chemputer equipped with a finite, but extensible, set of reagents, catalysts and process conditions, together with a chempiler that maps reaction graphs onto hardware, is universal: it can generate any stable, isolable molecule in finite time and in analytically detectable quantity, provided real-time error correction keeps the per-step fidelity above the threshold set by the molecule's assembly index. The proof is constructed by casting the platform as a Chemical Synthesis Turing Machine (CSTM). The CSTM formalism supplies (i) an eight-tuple state definition that unifies reagents, process variables (including catalysts) and tape operations; (ii) the Universal Chemputation Principle; and (iii) a dynamic-error-correction routine ensuring fault tolerant execution. Linking this framework to assembly theory strengthens the definition of a molecule by demanding practical synthesizability and error correction becomes a prerequisite for universality. We validate the abstraction against >100 \c{hi}DL programs executed on a modular chemputer rigs spanning single step to multi-step routes. Mapping each procedure onto CSTM shows that the cumulative number of unit operations grows linearly with synthetic depth. Together, these results elevate chemical synthesis to the status of a general computation: algorithms written in \c{hi}DL are compiled to hardware, executed with closed-loop correction, and produce verifiable molecular outputs. By formalising chemistry in this way, the chemputer offers a path to shareable, executable chemical code, interoperable hardware ecosystems, and ultimately a searchable, provable atlas of chemical space. |
| title | Chemputer and Chemputation -- A Universal Chemical Compound Synthesis Machine |
| topic | Emerging Technologies Chemical Physics |
| url | https://arxiv.org/abs/2408.09171 |