Mechanics promotes coherence in heterogeneous active media
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arXiv
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866911996065087488 |
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| author | Zimik, Soling Sinha, Sitabhra |
| author_facet | Zimik, Soling Sinha, Sitabhra |
| contents | Synchronization of activity among myocytes constituting vital organs, e.g., the heart, is crucial for physiological functions. Self-organized coordination in such heterogeneous ensemble of excitable and oscillatory cells is therefore of clinical importance. We show by varying the strength of intercellular coupling and the electrophysiological diversity, a wide range of collective behavior emerges including clusters of synchronized activity. Strikingly, stretch-activated currents allow waves of mechanical deformation to alter the activity of neighboring cells, promoting robust global coherence. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2408_10603 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Mechanics promotes coherence in heterogeneous active media Zimik, Soling Sinha, Sitabhra Tissues and Organs Pattern Formation and Solitons Biological Physics Synchronization of activity among myocytes constituting vital organs, e.g., the heart, is crucial for physiological functions. Self-organized coordination in such heterogeneous ensemble of excitable and oscillatory cells is therefore of clinical importance. We show by varying the strength of intercellular coupling and the electrophysiological diversity, a wide range of collective behavior emerges including clusters of synchronized activity. Strikingly, stretch-activated currents allow waves of mechanical deformation to alter the activity of neighboring cells, promoting robust global coherence. |
| title | Mechanics promotes coherence in heterogeneous active media |
| topic | Tissues and Organs Pattern Formation and Solitons Biological Physics |
| url | https://arxiv.org/abs/2408.10603 |