Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight
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arXiv
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| Autores principales: | , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| _version_ | 1866910578678693888 |
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| author | Ali, Nilufar Beheshti, Afshin Hampikian, Greg |
| author_facet | Ali, Nilufar Beheshti, Afshin Hampikian, Greg |
| contents | A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction. We identified specific Parkinson's genes differentially expressed post-spaceflight. These evidences indicate that spaceflight stressor-induced changes in the brain may become permanent during deep space exploration, posing a risk of PD in astronauts |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2408_15021 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight Ali, Nilufar Beheshti, Afshin Hampikian, Greg Other Quantitative Biology A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction. We identified specific Parkinson's genes differentially expressed post-spaceflight. These evidences indicate that spaceflight stressor-induced changes in the brain may become permanent during deep space exploration, posing a risk of PD in astronauts |
| title | Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight |
| topic | Other Quantitative Biology |
| url | https://arxiv.org/abs/2408.15021 |