Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://arxiv.org/abs/2408.15264 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866915098050691072 |
|---|---|
| author | Fuellen, Georg Kulaga, Anton Lobentanzer, Sebastian Unfried, Maximilian Avelar, Roberto Palmer, Daniel Kennedy, Brian K. |
| author_facet | Fuellen, Georg Kulaga, Anton Lobentanzer, Sebastian Unfried, Maximilian Avelar, Roberto Palmer, Daniel Kennedy, Brian K. |
| contents | The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluations should be correct, useful, comprehensive, explainable, and they should consider causality, interdisciplinarity, adherence to standards, longitudinal data and known aging biology. In particular, comprehensive analyses should go beyond comparing data based on canonical biomedical databases, suggesting the use of AI to interpret changes in biomarkers and outcomes. Our requirements motivate the use of LLMs with Knowledge Graphs and dedicated workflows employing, e.g., Retrieval-Augmented Generation. While naive trust in the responses of AI tools can cause harm, adding our requirements to LLM queries can improve response quality, calling for benchmarking efforts and justifying the informed use of LLMs for advice on longevity interventions. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2408_15264 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice Fuellen, Georg Kulaga, Anton Lobentanzer, Sebastian Unfried, Maximilian Avelar, Roberto Palmer, Daniel Kennedy, Brian K. Human-Computer Interaction 68T01 General topics in artificial intelligence The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluations should be correct, useful, comprehensive, explainable, and they should consider causality, interdisciplinarity, adherence to standards, longitudinal data and known aging biology. In particular, comprehensive analyses should go beyond comparing data based on canonical biomedical databases, suggesting the use of AI to interpret changes in biomarkers and outcomes. Our requirements motivate the use of LLMs with Knowledge Graphs and dedicated workflows employing, e.g., Retrieval-Augmented Generation. While naive trust in the responses of AI tools can cause harm, adding our requirements to LLM queries can improve response quality, calling for benchmarking efforts and justifying the informed use of LLMs for advice on longevity interventions. |
| title | Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice |
| topic | Human-Computer Interaction 68T01 General topics in artificial intelligence |
| url | https://arxiv.org/abs/2408.15264 |