Transient contacts between filaments impart its elasticity to branched actin
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arXiv
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| Autores principales: | , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| _version_ | 1866909308506079232 |
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| author | Bouzid, Mehdi Gallardo, Cesar Valencia Kopec, Magdalena Koehler, Lara Foffi, Giuseppe Roure, Olivia du Heuvingh, Julien Lenz, Martin |
| author_facet | Bouzid, Mehdi Gallardo, Cesar Valencia Kopec, Magdalena Koehler, Lara Foffi, Giuseppe Roure, Olivia du Heuvingh, Julien Lenz, Martin |
| contents | Branched actin networks exert pushing forces in eukaryotic cells, and adapt their stiffness to their environment. The physical basis for their mechanics and adaptability is however not understood. Indeed, here we show that their high density and low connectivity place them outside the scope of standard elastic network models for actin. We combine high-precision mechanical experiments, molecular dynamics simulations and a mean-field elastic theory to show that they are instead dominated by the proliferation of interfilament contacts under compression. This places branched actin in the same category as undercoordinated, fibrous materials such as sheep's wool. When the network is grown under force, filaments entangle as if knitted together and trap contacts in their structure. Trapped contacts play a similar role as crosslinkers in rigidifying the network, and are thus key to its active adaptive mechanics. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_00549 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Transient contacts between filaments impart its elasticity to branched actin Bouzid, Mehdi Gallardo, Cesar Valencia Kopec, Magdalena Koehler, Lara Foffi, Giuseppe Roure, Olivia du Heuvingh, Julien Lenz, Martin Soft Condensed Matter Biological Physics Subcellular Processes Branched actin networks exert pushing forces in eukaryotic cells, and adapt their stiffness to their environment. The physical basis for their mechanics and adaptability is however not understood. Indeed, here we show that their high density and low connectivity place them outside the scope of standard elastic network models for actin. We combine high-precision mechanical experiments, molecular dynamics simulations and a mean-field elastic theory to show that they are instead dominated by the proliferation of interfilament contacts under compression. This places branched actin in the same category as undercoordinated, fibrous materials such as sheep's wool. When the network is grown under force, filaments entangle as if knitted together and trap contacts in their structure. Trapped contacts play a similar role as crosslinkers in rigidifying the network, and are thus key to its active adaptive mechanics. |
| title | Transient contacts between filaments impart its elasticity to branched actin |
| topic | Soft Condensed Matter Biological Physics Subcellular Processes |
| url | https://arxiv.org/abs/2409.00549 |