Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers
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| Main Authors: | , , , , , |
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| Format: | Preprint |
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2024
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| _version_ | 1866912018146000896 |
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| author | Sadhukhan, Shubhadeep Martinez-Torres, Cristina Penič, Samo Beta, Carsten Iglič, Aleš Gov, Nir S |
| author_facet | Sadhukhan, Shubhadeep Martinez-Torres, Cristina Penič, Samo Beta, Carsten Iglič, Aleš Gov, Nir S |
| contents | Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the intracellular transport of polarity cues due to the global actin retrograde flow. This mechanism was termed the ``Universal Coupling between cell Speed and Persistency"(UCSP). Here we implemented a simplified version of the UCSP mechanism in a coarse-grained ``minimal-cell" model, which is composed of a three-dimensional vesicle that contains curved active proteins. This model spontaneously forms a lamellipodia-like motile cell shape, which is however sensitive and can depolarize into a non-motile form due to random fluctuations or when interacting with external obstacles. The UCSP implementation introduces long-range inhibition, which stabilizes the motile phenotype. This allows our model to describe the robust polarity observed in cells and explain a large variety of cellular dynamics, such as the relation between cell speed and aspect ratio, cell-barrier scattering, and cellular oscillations in different types of geometric confinements. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_04772 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers Sadhukhan, Shubhadeep Martinez-Torres, Cristina Penič, Samo Beta, Carsten Iglič, Aleš Gov, Nir S Biological Physics Cell Behavior Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the intracellular transport of polarity cues due to the global actin retrograde flow. This mechanism was termed the ``Universal Coupling between cell Speed and Persistency"(UCSP). Here we implemented a simplified version of the UCSP mechanism in a coarse-grained ``minimal-cell" model, which is composed of a three-dimensional vesicle that contains curved active proteins. This model spontaneously forms a lamellipodia-like motile cell shape, which is however sensitive and can depolarize into a non-motile form due to random fluctuations or when interacting with external obstacles. The UCSP implementation introduces long-range inhibition, which stabilizes the motile phenotype. This allows our model to describe the robust polarity observed in cells and explain a large variety of cellular dynamics, such as the relation between cell speed and aspect ratio, cell-barrier scattering, and cellular oscillations in different types of geometric confinements. |
| title | Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers |
| topic | Biological Physics Cell Behavior |
| url | https://arxiv.org/abs/2409.04772 |