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| Format: | Preprint |
| Veröffentlicht: |
2024
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| Online-Zugang: | https://arxiv.org/abs/2409.12482 |
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| _version_ | 1866915545028231168 |
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| author | Yamagishi, Jumpei F. Hatakeyama, Tetsuhiro S. |
| author_facet | Yamagishi, Jumpei F. Hatakeyama, Tetsuhiro S. |
| contents | Monod's law is a widely accepted phenomenology for bacterial growth. Since it has the same functional form as the Michaelis--Menten equation for enzyme kinetics, cell growth is often considered to be locally constrained by a single reaction. In contrast, this paper shows that a global constraint principle of resource allocation to metabolic processes can well describe the nature of cell growth. This concept is a generalization of Liebig's law, a growth law for higher organisms, and explains the dependence of microbial growth on the availability of multiple nutrients, in contrast to Monod's law. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_12482 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Global Constraint Principle for Microbial Growth Law Yamagishi, Jumpei F. Hatakeyama, Tetsuhiro S. Cell Behavior Monod's law is a widely accepted phenomenology for bacterial growth. Since it has the same functional form as the Michaelis--Menten equation for enzyme kinetics, cell growth is often considered to be locally constrained by a single reaction. In contrast, this paper shows that a global constraint principle of resource allocation to metabolic processes can well describe the nature of cell growth. This concept is a generalization of Liebig's law, a growth law for higher organisms, and explains the dependence of microbial growth on the availability of multiple nutrients, in contrast to Monod's law. |
| title | Global Constraint Principle for Microbial Growth Law |
| topic | Cell Behavior |
| url | https://arxiv.org/abs/2409.12482 |