Ortho-positronium Lifetime For Soft-tissue Classification
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arXiv
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| Auteurs principaux: | , , , , , , |
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| Format: | Preprint |
| Publié: |
2024
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| _version_ | 1866910613797601280 |
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| author | Avachat, Ashish V. Mahmoud, Kholod H. Leja, Anthony G. Xu, Jiajie J. Anastasio, Mark A. Sivaguru, Mayandi Di Fulvio, Angela |
| author_facet | Avachat, Ashish V. Mahmoud, Kholod H. Leja, Anthony G. Xu, Jiajie J. Anastasio, Mark A. Sivaguru, Mayandi Di Fulvio, Angela |
| contents | The objective of this work is to showcase the ortho-positronium lifetime as a probe for soft-tissue characterization. We employed positron annihilation lifetime spectroscopy to experimentally measure the three components of the positron annihilation lifetime para-positronium (p-Ps), positron, and ortho-positronium (o-Ps) for three types of porcine, non-fixated soft tissues ex vivo: adipose, hepatic, and muscle.Then, we benchmarked our measurements with X-ray phase-contrast imaging, which is the current state-of-the-art for soft-tissue analysis. We found that the o-Ps lifetime in adipose tissues (2.54+/-0.12) ns was approximately 20\% longer than in hepatic (2.04+/-0.09 ns) and muscle (2.03+/-0.12 ns) tissues .In addition, the separation between the measurements for adipose tissue and the other tissues was better from o-Ps lifetime measurement than from X-ray phase-contrast imaging. This experimental study proved that the o-Ps lifetime is a viable non-invasive probe for characterizing and classifying the different soft tissues. Specifically, o-Ps lifetime as a soft-tissue characterization probe had a strong sensitivity to the lipid content that can be potentially implemented in commercial positron emission tomography scanners that feature list-mode data acquisition. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_13102 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Ortho-positronium Lifetime For Soft-tissue Classification Avachat, Ashish V. Mahmoud, Kholod H. Leja, Anthony G. Xu, Jiajie J. Anastasio, Mark A. Sivaguru, Mayandi Di Fulvio, Angela Instrumentation and Detectors The objective of this work is to showcase the ortho-positronium lifetime as a probe for soft-tissue characterization. We employed positron annihilation lifetime spectroscopy to experimentally measure the three components of the positron annihilation lifetime para-positronium (p-Ps), positron, and ortho-positronium (o-Ps) for three types of porcine, non-fixated soft tissues ex vivo: adipose, hepatic, and muscle.Then, we benchmarked our measurements with X-ray phase-contrast imaging, which is the current state-of-the-art for soft-tissue analysis. We found that the o-Ps lifetime in adipose tissues (2.54+/-0.12) ns was approximately 20\% longer than in hepatic (2.04+/-0.09 ns) and muscle (2.03+/-0.12 ns) tissues .In addition, the separation between the measurements for adipose tissue and the other tissues was better from o-Ps lifetime measurement than from X-ray phase-contrast imaging. This experimental study proved that the o-Ps lifetime is a viable non-invasive probe for characterizing and classifying the different soft tissues. Specifically, o-Ps lifetime as a soft-tissue characterization probe had a strong sensitivity to the lipid content that can be potentially implemented in commercial positron emission tomography scanners that feature list-mode data acquisition. |
| title | Ortho-positronium Lifetime For Soft-tissue Classification |
| topic | Instrumentation and Detectors |
| url | https://arxiv.org/abs/2409.13102 |