First image-guided treatment of a mouse tumor with radioactive ion beams
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arXiv
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| Autori principali: | , , , , , , , , , , , , , , , , , , |
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| Natura: | Preprint |
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2024
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| author | Boscolo, Daria Lovatti, Giulio Sokol, Olga Vitacchio, Tamara Evangelista, Francesco Haettner, Emma Tinganelli, Walter Graeff, Christian Weber, Uli Schuy, Christoph Nitta, Munetaka Moglioni, Martina Kostyleva, Daria Purushothaman, Sivaji Thirolf, Peter G. Bortfeldt, Jonathan Scheidenberger, Christoph Parodi, Katia Durante, Marco |
| author_facet | Boscolo, Daria Lovatti, Giulio Sokol, Olga Vitacchio, Tamara Evangelista, Francesco Haettner, Emma Tinganelli, Walter Graeff, Christian Weber, Uli Schuy, Christoph Nitta, Munetaka Moglioni, Martina Kostyleva, Daria Purushothaman, Sivaji Thirolf, Peter G. Bortfeldt, Jonathan Scheidenberger, Christoph Parodi, Katia Durante, Marco |
| contents | Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most effective radiotherapy technique available, it is highly susceptible to uncertainties in the beam range. RIB are well-suited for image-guided particle therapy, as isotopes that undergo \b{eta}+-decay can be precisely visualized using positron emission tomography (PET), enabling accurate real-time monitoring of the beam range. We successfully treated a mouse osteosarcoma using a radioactive 11C-ion beam. The tumor was located in the neck, in close proximity to the spinal cord, increasing the risk of radiation-induced myelopathy from even slight variations in the beam range caused by anatomical changes or incorrect calibration of the planning CT. We managed to completely control the tumor with the highest dose while minimizing toxicity. Low-grade neurological side effects were correlated to the positron activity measured in the spine. The biological washout of the activity from the tumor volume was dependent on the dose, indicating a potential component of vascular damage at high doses. This experiment marks the first instance of tumor treatment using RIB and paves the way for future clinical applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_14898 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | First image-guided treatment of a mouse tumor with radioactive ion beams Boscolo, Daria Lovatti, Giulio Sokol, Olga Vitacchio, Tamara Evangelista, Francesco Haettner, Emma Tinganelli, Walter Graeff, Christian Weber, Uli Schuy, Christoph Nitta, Munetaka Moglioni, Martina Kostyleva, Daria Purushothaman, Sivaji Thirolf, Peter G. Bortfeldt, Jonathan Scheidenberger, Christoph Parodi, Katia Durante, Marco Medical Physics Nuclear Experiment Accelerator Physics Applied Physics Biological Physics Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most effective radiotherapy technique available, it is highly susceptible to uncertainties in the beam range. RIB are well-suited for image-guided particle therapy, as isotopes that undergo \b{eta}+-decay can be precisely visualized using positron emission tomography (PET), enabling accurate real-time monitoring of the beam range. We successfully treated a mouse osteosarcoma using a radioactive 11C-ion beam. The tumor was located in the neck, in close proximity to the spinal cord, increasing the risk of radiation-induced myelopathy from even slight variations in the beam range caused by anatomical changes or incorrect calibration of the planning CT. We managed to completely control the tumor with the highest dose while minimizing toxicity. Low-grade neurological side effects were correlated to the positron activity measured in the spine. The biological washout of the activity from the tumor volume was dependent on the dose, indicating a potential component of vascular damage at high doses. This experiment marks the first instance of tumor treatment using RIB and paves the way for future clinical applications. |
| title | First image-guided treatment of a mouse tumor with radioactive ion beams |
| topic | Medical Physics Nuclear Experiment Accelerator Physics Applied Physics Biological Physics |
| url | https://arxiv.org/abs/2409.14898 |