An R package for nonparametric inference on dynamic populations with infinitely many types
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| Format: | Preprint |
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2024
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| _version_ | 1866917184943423488 |
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| author | Ascolani, Filippo Damato, Stefano Ruggiero, Matteo |
| author_facet | Ascolani, Filippo Damato, Stefano Ruggiero, Matteo |
| contents | Fleming-Viot diffusions are widely used stochastic models for population dynamics which extend the celebrated Wright-Fisher diffusions. They describe the temporal evolution of the relative frequencies of the allelic types in an ideally infinite panmictic population, whose individuals undergo random genetic drift and at birth can mutate to a new allelic type drawn from a possibly infinite potential pool, independently of their parent. Recently, Bayesian nonparametric inference has been considered for this model when a finite sample of individuals is drawn from the population at several discrete time points. Previous works have fully described the relevant estimators for this problem, but current software is available only for the Wright-Fisher finite-dimensional case. Here we provide software for the general case, overcoming some non trivial computational challenges posed by this setting. The R package FVDDPpkg efficiently approximates the filtering and smoothing distribution for Fleming-Viot diffusions, given finite samples of individuals collected at different times. A suitable Monte Carlo approximation is also introduced in order to reduce the computational cost. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2409_15539 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | An R package for nonparametric inference on dynamic populations with infinitely many types Ascolani, Filippo Damato, Stefano Ruggiero, Matteo Computation Probability Populations and Evolution Quantitative Methods Applications Fleming-Viot diffusions are widely used stochastic models for population dynamics which extend the celebrated Wright-Fisher diffusions. They describe the temporal evolution of the relative frequencies of the allelic types in an ideally infinite panmictic population, whose individuals undergo random genetic drift and at birth can mutate to a new allelic type drawn from a possibly infinite potential pool, independently of their parent. Recently, Bayesian nonparametric inference has been considered for this model when a finite sample of individuals is drawn from the population at several discrete time points. Previous works have fully described the relevant estimators for this problem, but current software is available only for the Wright-Fisher finite-dimensional case. Here we provide software for the general case, overcoming some non trivial computational challenges posed by this setting. The R package FVDDPpkg efficiently approximates the filtering and smoothing distribution for Fleming-Viot diffusions, given finite samples of individuals collected at different times. A suitable Monte Carlo approximation is also introduced in order to reduce the computational cost. |
| title | An R package for nonparametric inference on dynamic populations with infinitely many types |
| topic | Computation Probability Populations and Evolution Quantitative Methods Applications |
| url | https://arxiv.org/abs/2409.15539 |