Cellular Griffiths-like phase
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arXiv
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| Main Authors: | , , , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866912046650490880 |
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| author | Squillante, Lucas Mello, Isys F. Ricco, Luciano S. Minicucci, Marcos F. Ukpong, Aniekan Magnus Seridonio, Antonio C. Lagos-Monaco, Roberto E. de Souza, Mariano |
| author_facet | Squillante, Lucas Mello, Isys F. Ricco, Luciano S. Minicucci, Marcos F. Ukpong, Aniekan Magnus Seridonio, Antonio C. Lagos-Monaco, Roberto E. de Souza, Mariano |
| contents | Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_17292 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Cellular Griffiths-like phase Squillante, Lucas Mello, Isys F. Ricco, Luciano S. Minicucci, Marcos F. Ukpong, Aniekan Magnus Seridonio, Antonio C. Lagos-Monaco, Roberto E. de Souza, Mariano Biological Physics Statistical Mechanics Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes. |
| title | Cellular Griffiths-like phase |
| topic | Biological Physics Statistical Mechanics |
| url | https://arxiv.org/abs/2409.17292 |