Growing length and time scales in activity-mediated glassy dynamics in confluent cell monolayers
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arXiv
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| Format: | Preprint |
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2024
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| _version_ | 1866913829065064448 |
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| author | Sadhukhan, Souvik Dasgupta, Chandan Nandi, Saroj Kumar |
| author_facet | Sadhukhan, Souvik Dasgupta, Chandan Nandi, Saroj Kumar |
| contents | Activity-mediated unjamming of a confluent glassy system is crucial for several biological processes, such as embryogenesis and cancer metastasis. During these processes, the cells progressively change their junction properties, characterized by an interaction parameter $p_0$, and become motile. Here, we study the effect of nonequilibrium active fluctuations, in the form of self-propulsion, on the glassy dynamics in a confluent system. We simulate the active Vertex model and use the analytical mode-coupling theory (MCT) to show that the nature of the transition in the presence of activity remains similar to that in a thermal system where the fluctuations are temperature-like. The agreement of the simulation results with the MCT predictions demonstrates that the structure-dynamics feedback mechanism controls the relaxation dynamics. In addition, we present the first computation of a dynamic length scale, $ξ_d$, in confluent systems using finite-size scaling, and show that the growing relaxation time exhibita a power-law dependence on $ξ_d$. Furthermore, unlike particulate glasses, the static length that governs the finite-size scaling of the relaxation time is proportional to $ξ_d$, revealing the unique nature of the glassy dynamics in confluent systems. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_17816 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Growing length and time scales in activity-mediated glassy dynamics in confluent cell monolayers Sadhukhan, Souvik Dasgupta, Chandan Nandi, Saroj Kumar Soft Condensed Matter Biological Physics Activity-mediated unjamming of a confluent glassy system is crucial for several biological processes, such as embryogenesis and cancer metastasis. During these processes, the cells progressively change their junction properties, characterized by an interaction parameter $p_0$, and become motile. Here, we study the effect of nonequilibrium active fluctuations, in the form of self-propulsion, on the glassy dynamics in a confluent system. We simulate the active Vertex model and use the analytical mode-coupling theory (MCT) to show that the nature of the transition in the presence of activity remains similar to that in a thermal system where the fluctuations are temperature-like. The agreement of the simulation results with the MCT predictions demonstrates that the structure-dynamics feedback mechanism controls the relaxation dynamics. In addition, we present the first computation of a dynamic length scale, $ξ_d$, in confluent systems using finite-size scaling, and show that the growing relaxation time exhibita a power-law dependence on $ξ_d$. Furthermore, unlike particulate glasses, the static length that governs the finite-size scaling of the relaxation time is proportional to $ξ_d$, revealing the unique nature of the glassy dynamics in confluent systems. |
| title | Growing length and time scales in activity-mediated glassy dynamics in confluent cell monolayers |
| topic | Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2409.17816 |