Active morphodynamics of intracellular organelles in the trafficking pathway
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arXiv
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| Format: | Preprint |
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2024
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| _version_ | 1866916495689252864 |
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| author | Rautu, S. Alex Morris, Richard G. Rao, Madan |
| author_facet | Rautu, S. Alex Morris, Richard G. Rao, Madan |
| contents | From the Golgi apparatus to endosomes, organelles in the endomembrane system exhibit complex and varied morphologies that are often related to their function. Such membrane-bound organelles operate far from equilibrium due to directed fluxes of smaller trafficking vesicles; the physical principles governing the emergence and maintenance of these structures have thus remained elusive. By understanding individual fission and fusion events in terms of active mechano-chemical cycles, we show how such trafficking manifests at the hydrodynamic scale, resulting not only in fluxes of material -- such as membrane area and encapsulated volume -- but also in active stresses that drive momentum transfer between an organelle and its cytosolic environment. Due to the fluid and deformable nature of the bounding membrane, this gives rise to novel physics, coupling nonequilibrium forces to organelle composition, morphology and hydrodynamic flows. We demonstrate how both stable compartment drift and ramified sac-like morphologies, each reminiscent of Golgi-cisternae, emerge naturally from the same underlying nonequilibrium dynamics of fission and fusion. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2409_19084 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Active morphodynamics of intracellular organelles in the trafficking pathway Rautu, S. Alex Morris, Richard G. Rao, Madan Soft Condensed Matter Biological Physics Subcellular Processes From the Golgi apparatus to endosomes, organelles in the endomembrane system exhibit complex and varied morphologies that are often related to their function. Such membrane-bound organelles operate far from equilibrium due to directed fluxes of smaller trafficking vesicles; the physical principles governing the emergence and maintenance of these structures have thus remained elusive. By understanding individual fission and fusion events in terms of active mechano-chemical cycles, we show how such trafficking manifests at the hydrodynamic scale, resulting not only in fluxes of material -- such as membrane area and encapsulated volume -- but also in active stresses that drive momentum transfer between an organelle and its cytosolic environment. Due to the fluid and deformable nature of the bounding membrane, this gives rise to novel physics, coupling nonequilibrium forces to organelle composition, morphology and hydrodynamic flows. We demonstrate how both stable compartment drift and ramified sac-like morphologies, each reminiscent of Golgi-cisternae, emerge naturally from the same underlying nonequilibrium dynamics of fission and fusion. |
| title | Active morphodynamics of intracellular organelles in the trafficking pathway |
| topic | Soft Condensed Matter Biological Physics Subcellular Processes |
| url | https://arxiv.org/abs/2409.19084 |