Immunogenicity Prediction with Dual Attention Enables Vaccine Target Selection
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arXiv
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| Autores principales: | , , , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| Materias: | |
| Acceso en línea: | |
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| _version_ | 1866915290767425536 |
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| author | Li, Song Tan, Yang Ke, Song Hong, Liang Zhou, Bingxin |
| author_facet | Li, Song Tan, Yang Ke, Song Hong, Liang Zhou, Bingxin |
| contents | Immunogenicity prediction is a central topic in reverse vaccinology for finding candidate vaccines that can trigger protective immune responses. Existing approaches typically rely on highly compressed features and simple model architectures, leading to limited prediction accuracy and poor generalizability. To address these challenges, we introduce VenusVaccine, a novel deep learning solution with a dual attention mechanism that integrates pre-trained latent vector representations of protein sequences and structures. We also compile the most comprehensive immunogenicity dataset to date, encompassing over 7000 antigen sequences, structures, and immunogenicity labels from bacteria, virus, and tumor. Extensive experiments demonstrate that VenusVaccine outperforms existing methods across a wide range of evaluation metrics. Furthermore, we establish a post-hoc validation protocol to assess the practical significance of deep learning models in tackling vaccine design challenges. Our work provides an effective tool for vaccine design and sets valuable benchmarks for future research. The implementation is at https://github.com/songleee/VenusVaccine. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_02647 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Immunogenicity Prediction with Dual Attention Enables Vaccine Target Selection Li, Song Tan, Yang Ke, Song Hong, Liang Zhou, Bingxin Machine Learning Computation and Language Biomolecules Immunogenicity prediction is a central topic in reverse vaccinology for finding candidate vaccines that can trigger protective immune responses. Existing approaches typically rely on highly compressed features and simple model architectures, leading to limited prediction accuracy and poor generalizability. To address these challenges, we introduce VenusVaccine, a novel deep learning solution with a dual attention mechanism that integrates pre-trained latent vector representations of protein sequences and structures. We also compile the most comprehensive immunogenicity dataset to date, encompassing over 7000 antigen sequences, structures, and immunogenicity labels from bacteria, virus, and tumor. Extensive experiments demonstrate that VenusVaccine outperforms existing methods across a wide range of evaluation metrics. Furthermore, we establish a post-hoc validation protocol to assess the practical significance of deep learning models in tackling vaccine design challenges. Our work provides an effective tool for vaccine design and sets valuable benchmarks for future research. The implementation is at https://github.com/songleee/VenusVaccine. |
| title | Immunogenicity Prediction with Dual Attention Enables Vaccine Target Selection |
| topic | Machine Learning Computation and Language Biomolecules |
| url | https://arxiv.org/abs/2410.02647 |