Longitudinal photoacoustic monitoring of collagen evolution modulated by cancer-associated fibroblasts: simulation and experiment studies
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arXiv
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| Auteurs principaux: | , , , , |
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| Format: | Preprint |
| Publié: |
2024
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| _version_ | 1866910633165848576 |
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| author | Li, Jiayan Bai, Lu Cao, Junmei Zhi, Wenxiang Cheng, Qian |
| author_facet | Li, Jiayan Bai, Lu Cao, Junmei Zhi, Wenxiang Cheng, Qian |
| contents | Noninvasive in vivo detection of collagen facilitates the investigation of mechanisms by which cancer-associated fibroblast (CAF) regulates the extracellular matrix. This study explored the feasibility of photoacoustic spectrum analysis (PASA) in identifying longitudinal changes of collagen modulated by CAFs using simulations and experiment studies. Optical and acoustic simulations in tissues were performed based on the histological slides of maximum cross-sections of murine malignancies to verify the effectiveness of photoacoustic (PA) detection system and the parameter "relative area of power spectrum density (APSD)". Experiments were conducted on three groups of mouse models with incremental ratios of CAFs and breast cancer cells at 3 continuous time points. Results discovered that the system configuration and APSD were capable of reflecting the evolution of collagen during cancer growth. Furthermore, cancers receiving a high dose of CAFs exhibited a suppressed collagen level. The presented methods show great potential for clinical translation of PASA in the field of cancer therapies targeting CAFs. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_03324 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Longitudinal photoacoustic monitoring of collagen evolution modulated by cancer-associated fibroblasts: simulation and experiment studies Li, Jiayan Bai, Lu Cao, Junmei Zhi, Wenxiang Cheng, Qian Biological Physics Tissues and Organs Noninvasive in vivo detection of collagen facilitates the investigation of mechanisms by which cancer-associated fibroblast (CAF) regulates the extracellular matrix. This study explored the feasibility of photoacoustic spectrum analysis (PASA) in identifying longitudinal changes of collagen modulated by CAFs using simulations and experiment studies. Optical and acoustic simulations in tissues were performed based on the histological slides of maximum cross-sections of murine malignancies to verify the effectiveness of photoacoustic (PA) detection system and the parameter "relative area of power spectrum density (APSD)". Experiments were conducted on three groups of mouse models with incremental ratios of CAFs and breast cancer cells at 3 continuous time points. Results discovered that the system configuration and APSD were capable of reflecting the evolution of collagen during cancer growth. Furthermore, cancers receiving a high dose of CAFs exhibited a suppressed collagen level. The presented methods show great potential for clinical translation of PASA in the field of cancer therapies targeting CAFs. |
| title | Longitudinal photoacoustic monitoring of collagen evolution modulated by cancer-associated fibroblasts: simulation and experiment studies |
| topic | Biological Physics Tissues and Organs |
| url | https://arxiv.org/abs/2410.03324 |