Photoacoustic tracking of photo-magnetically powered nanoparticles for cancer therapy
Fuente:
arXiv
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2024
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866929527821697024 |
|---|---|
| author | Li, Jiayan Xu, Chang Chen, Yingna Cao, Junmei Ye, Wanli Cheng, Yu Cheng, Qian |
| author_facet | Li, Jiayan Xu, Chang Chen, Yingna Cao, Junmei Ye, Wanli Cheng, Yu Cheng, Qian |
| contents | The in vivo propulsion and monitoring of nanoparticles (NPs) have received tremendous achievements in the past decade. Developing functional NPs that can be efficiently manipulated inside the human body with a non-invasive tracking modality is critical to clinical translation. This study synthesized a photo-magnetically powered nanoparticle (PMN) with a Fe3O4 core and gold spiky surface. The Au-nanotips ensure PMNs have a strong light absorption in the second near-infrared (NIR) window and produce outstanding photoacoustic signals. The Bio-transmission electron microscopy and simulation results prove that the assembly of PMNs under a magnetic field further enhances the photothermal conversion in cells, contributing to the reduction of ambient viscosity. Photoacoustic imaging (PAI) realized real-time monitoring of PMN movements and revealed that laser plus magnetic coupling couldimprove intratumoral distribution and retention. The proposed methods exhibit excellent potential for the clinical research of cancer nanotherapies. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_03404 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Photoacoustic tracking of photo-magnetically powered nanoparticles for cancer therapy Li, Jiayan Xu, Chang Chen, Yingna Cao, Junmei Ye, Wanli Cheng, Yu Cheng, Qian Biological Physics Medical Physics The in vivo propulsion and monitoring of nanoparticles (NPs) have received tremendous achievements in the past decade. Developing functional NPs that can be efficiently manipulated inside the human body with a non-invasive tracking modality is critical to clinical translation. This study synthesized a photo-magnetically powered nanoparticle (PMN) with a Fe3O4 core and gold spiky surface. The Au-nanotips ensure PMNs have a strong light absorption in the second near-infrared (NIR) window and produce outstanding photoacoustic signals. The Bio-transmission electron microscopy and simulation results prove that the assembly of PMNs under a magnetic field further enhances the photothermal conversion in cells, contributing to the reduction of ambient viscosity. Photoacoustic imaging (PAI) realized real-time monitoring of PMN movements and revealed that laser plus magnetic coupling couldimprove intratumoral distribution and retention. The proposed methods exhibit excellent potential for the clinical research of cancer nanotherapies. |
| title | Photoacoustic tracking of photo-magnetically powered nanoparticles for cancer therapy |
| topic | Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2410.03404 |