Rosette spectroscopic imaging for whole-brain metabolite mapping at 7T: acceleration potential and reproducibility
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| Format: | Preprint |
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2024
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| _version_ | 1866912062206115840 |
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| author | Huang, Zhiwei Emir, Uzay Doring, Andre Klauser, Antoine Xiao, Ying Widmaier, Mark Xin, Lijing |
| author_facet | Huang, Zhiwei Emir, Uzay Doring, Andre Klauser, Antoine Xiao, Ying Widmaier, Mark Xin, Lijing |
| contents | Whole-brain proton magnetic resonance spectroscopic imaging (1H-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly benefits from the improved SNR at ultrahigh field strengths ($\geq$7T). However, 1H-MRSI still faces several challenges, such as long acquisition time and severe signal contaminations from water and lipids. In this study, 2D and 3D short TR/TE 1H-FID-MRSI sequences using rosette trajectories were developed with spatial resolutions of 4.48$\times$4.48 mm$^2$ and 4.48$\times$4.48$\times$4.50 mm$^3$, respectively. Water signals were suppressed using an optimized Five-variable-Angle-gaussian-pulses-with-ShorT-total-duration of 76 ms (FAST) water suppression scheme, and lipid signals were removed using the L2 regularization method. Metabolic maps of major 1H metabolites were obtained within 5:40 min with 16 averages and 1 average for the 2D and 3D acquisitions, respectively. Excellent inter-session reproducibility was shown, with the coefficients of variance (CV) being lower than 6% for N-Acetyle-L-aspartic acid (NAA), Glutamate (Glu), Choline Chloride and glycerophosphocholine (tCho), Creatine and Phosphocreatine (tCr), and Glycine and Myo-inositol (Gly+Ins). To explore the potential of further accelerating the acquisition, compressed sensing was applied retrospectively to the 3D datasets. The structural similarity index (SSIM) remained above 0.85 and 0.8 until $R = 2$ and $R = 3$ for the metabolite maps of Glu, NAA, tCr, and tCho, indicating the possibility for further reduction of acquisition time to around 2min. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2410_05245 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Rosette spectroscopic imaging for whole-brain metabolite mapping at 7T: acceleration potential and reproducibility Huang, Zhiwei Emir, Uzay Doring, Andre Klauser, Antoine Xiao, Ying Widmaier, Mark Xin, Lijing Medical Physics Whole-brain proton magnetic resonance spectroscopic imaging (1H-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly benefits from the improved SNR at ultrahigh field strengths ($\geq$7T). However, 1H-MRSI still faces several challenges, such as long acquisition time and severe signal contaminations from water and lipids. In this study, 2D and 3D short TR/TE 1H-FID-MRSI sequences using rosette trajectories were developed with spatial resolutions of 4.48$\times$4.48 mm$^2$ and 4.48$\times$4.48$\times$4.50 mm$^3$, respectively. Water signals were suppressed using an optimized Five-variable-Angle-gaussian-pulses-with-ShorT-total-duration of 76 ms (FAST) water suppression scheme, and lipid signals were removed using the L2 regularization method. Metabolic maps of major 1H metabolites were obtained within 5:40 min with 16 averages and 1 average for the 2D and 3D acquisitions, respectively. Excellent inter-session reproducibility was shown, with the coefficients of variance (CV) being lower than 6% for N-Acetyle-L-aspartic acid (NAA), Glutamate (Glu), Choline Chloride and glycerophosphocholine (tCho), Creatine and Phosphocreatine (tCr), and Glycine and Myo-inositol (Gly+Ins). To explore the potential of further accelerating the acquisition, compressed sensing was applied retrospectively to the 3D datasets. The structural similarity index (SSIM) remained above 0.85 and 0.8 until $R = 2$ and $R = 3$ for the metabolite maps of Glu, NAA, tCr, and tCho, indicating the possibility for further reduction of acquisition time to around 2min. |
| title | Rosette spectroscopic imaging for whole-brain metabolite mapping at 7T: acceleration potential and reproducibility |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2410.05245 |