Near-ideal selection for the Standard Genetic Code
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arXiv
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| Format: | Preprint |
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2024
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| _version_ | 1866916431902277632 |
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| author | Yarus, Michael |
| author_facet | Yarus, Michael |
| contents | Evolutionary theorizing resembles building an aircraft while also piloting it; new results change the scaffold for older ideas, requiring revised strategy to remain airborne. A calculated kinetic pathway exists that, under explicit quantitative assumptions, delivers the SGC (Standard Genetic Code). The pathway and evidence for it is summarized below, striving for a clearer, more complete account than was possible during its construction. Beginning with experimental amino acid-RNA interactions, code assignments are fused, codes divide and an early coding crescendo is tested for homogeneous assignments, which are then selected for independent survival in a near-empty biotic world. During escape from the site of origin and diaspora, a near-complete SGC becomes dominant by supporting proficient division. Crescendo, escape and diaspora together comprise a near-ideal least selection for a Standard Genetic Code that specifically served LUCA, likely a free-living anaerobic thermophilic microbe. Selection during diaspora conceivably made persistence across gigayears feasible. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_07814 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Near-ideal selection for the Standard Genetic Code Yarus, Michael Populations and Evolution Evolutionary theorizing resembles building an aircraft while also piloting it; new results change the scaffold for older ideas, requiring revised strategy to remain airborne. A calculated kinetic pathway exists that, under explicit quantitative assumptions, delivers the SGC (Standard Genetic Code). The pathway and evidence for it is summarized below, striving for a clearer, more complete account than was possible during its construction. Beginning with experimental amino acid-RNA interactions, code assignments are fused, codes divide and an early coding crescendo is tested for homogeneous assignments, which are then selected for independent survival in a near-empty biotic world. During escape from the site of origin and diaspora, a near-complete SGC becomes dominant by supporting proficient division. Crescendo, escape and diaspora together comprise a near-ideal least selection for a Standard Genetic Code that specifically served LUCA, likely a free-living anaerobic thermophilic microbe. Selection during diaspora conceivably made persistence across gigayears feasible. |
| title | Near-ideal selection for the Standard Genetic Code |
| topic | Populations and Evolution |
| url | https://arxiv.org/abs/2410.07814 |