Suppression of collision-induced dissociation in a supersonically expanding gas
Fuente:
arXiv
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866917915939307520 |
|---|---|
| author | Namangalam, Uma Mohandas, Salvi Dinesan, Hemanth S, Sunil Kumar |
| author_facet | Namangalam, Uma Mohandas, Salvi Dinesan, Hemanth S, Sunil Kumar |
| contents | In high-resolution mass spectrometry, an electrospray ionization source is often paired with an ion-funnel to enhance ion transmission. Although it is established that ions experience collision-induced dissociation as they pass through this device, the impact of gas-flow dynamics on ion fragmentation remains unexplored. The present work demonstrates that the gas-flow dynamics from the capillary interface of an electrospray ionization source into an ion-funnel significantly reduces ion fragmentation. This reduction stems from the substantial decrease in the rate of increase in the internal energy of the ions resulting from the collisions with a supersonically expanding gas. The results of this study have significant consequences for systems that employ electrospray mass spectrometry and ion-mobility spectrometry. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_15757 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Suppression of collision-induced dissociation in a supersonically expanding gas Namangalam, Uma Mohandas, Salvi Dinesan, Hemanth S, Sunil Kumar Atomic and Molecular Clusters In high-resolution mass spectrometry, an electrospray ionization source is often paired with an ion-funnel to enhance ion transmission. Although it is established that ions experience collision-induced dissociation as they pass through this device, the impact of gas-flow dynamics on ion fragmentation remains unexplored. The present work demonstrates that the gas-flow dynamics from the capillary interface of an electrospray ionization source into an ion-funnel significantly reduces ion fragmentation. This reduction stems from the substantial decrease in the rate of increase in the internal energy of the ions resulting from the collisions with a supersonically expanding gas. The results of this study have significant consequences for systems that employ electrospray mass spectrometry and ion-mobility spectrometry. |
| title | Suppression of collision-induced dissociation in a supersonically expanding gas |
| topic | Atomic and Molecular Clusters |
| url | https://arxiv.org/abs/2410.15757 |