Uncovering the Genetic Basis of Glioblastoma Heterogeneity through Multimodal Analysis of Whole Slide Images and RNA Sequencing Data
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arXiv
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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866910952425783296 |
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| author | Berjaoui, Ahmad Roussel, Louis Sanchez, Eduardo Hugo Moyal, Elizabeth Cohen-Jonathan |
| author_facet | Berjaoui, Ahmad Roussel, Louis Sanchez, Eduardo Hugo Moyal, Elizabeth Cohen-Jonathan |
| contents | Glioblastoma is a highly aggressive form of brain cancer characterized by rapid progression and poor prognosis. Despite advances in treatment, the underlying genetic mechanisms driving this aggressiveness remain poorly understood. In this study, we employed multimodal deep learning approaches to investigate glioblastoma heterogeneity using joint image/RNA-seq analysis. Our results reveal novel genes associated with glioblastoma. By leveraging a combination of whole-slide images and RNA-seq, as well as introducing novel methods to encode RNA-seq data, we identified specific genetic profiles that may explain different patterns of glioblastoma progression. These findings provide new insights into the genetic mechanisms underlying glioblastoma heterogeneity and highlight potential targets for therapeutic intervention. Code and data downloading instructions are available at: https://github.com/ma3oun/gbheterogeneity. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_18710 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Uncovering the Genetic Basis of Glioblastoma Heterogeneity through Multimodal Analysis of Whole Slide Images and RNA Sequencing Data Berjaoui, Ahmad Roussel, Louis Sanchez, Eduardo Hugo Moyal, Elizabeth Cohen-Jonathan Quantitative Methods Artificial Intelligence Glioblastoma is a highly aggressive form of brain cancer characterized by rapid progression and poor prognosis. Despite advances in treatment, the underlying genetic mechanisms driving this aggressiveness remain poorly understood. In this study, we employed multimodal deep learning approaches to investigate glioblastoma heterogeneity using joint image/RNA-seq analysis. Our results reveal novel genes associated with glioblastoma. By leveraging a combination of whole-slide images and RNA-seq, as well as introducing novel methods to encode RNA-seq data, we identified specific genetic profiles that may explain different patterns of glioblastoma progression. These findings provide new insights into the genetic mechanisms underlying glioblastoma heterogeneity and highlight potential targets for therapeutic intervention. Code and data downloading instructions are available at: https://github.com/ma3oun/gbheterogeneity. |
| title | Uncovering the Genetic Basis of Glioblastoma Heterogeneity through Multimodal Analysis of Whole Slide Images and RNA Sequencing Data |
| topic | Quantitative Methods Artificial Intelligence |
| url | https://arxiv.org/abs/2410.18710 |