Interferometric Mass Photometry at the Quantum Limit of Sensitivity
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arXiv
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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866908446281957376 |
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| author | Müller, Fabian Köse, Emre Meixner, Alfred J. Schäffer, Erik Braun, Daniel |
| author_facet | Müller, Fabian Köse, Emre Meixner, Alfred J. Schäffer, Erik Braun, Daniel |
| contents | We present an innovative optical imaging system for measuring parameters of a small particle such as a macromolecule or nanoparticle at the quantum limit of sensitivity. In comparison to the conventional confocal interferometric scattering (iSCAT) approach, our setup adds a second arm to form a Michelson interferometer that allows us to tune a relative phase. We evaluate the quantum Cramér-Rao bound (QCRB) for different quantum states, including single-mode coherent states, multi-frequency coherent states, and phase-averaged coherent states. Our results show that the proposed setup can achieve the QCRB of sensitivity and outperform iSCAT for all considered quantum states for mass and phase estimation of a particle. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_19417 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Interferometric Mass Photometry at the Quantum Limit of Sensitivity Müller, Fabian Köse, Emre Meixner, Alfred J. Schäffer, Erik Braun, Daniel Quantum Physics Instrumentation and Detectors Optics We present an innovative optical imaging system for measuring parameters of a small particle such as a macromolecule or nanoparticle at the quantum limit of sensitivity. In comparison to the conventional confocal interferometric scattering (iSCAT) approach, our setup adds a second arm to form a Michelson interferometer that allows us to tune a relative phase. We evaluate the quantum Cramér-Rao bound (QCRB) for different quantum states, including single-mode coherent states, multi-frequency coherent states, and phase-averaged coherent states. Our results show that the proposed setup can achieve the QCRB of sensitivity and outperform iSCAT for all considered quantum states for mass and phase estimation of a particle. |
| title | Interferometric Mass Photometry at the Quantum Limit of Sensitivity |
| topic | Quantum Physics Instrumentation and Detectors Optics |
| url | https://arxiv.org/abs/2410.19417 |