Multiparameter optimal control of F1-ATPase
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arXiv
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| Main Authors: | , |
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| Format: | Preprint |
| Published: |
2024
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| _version_ | 1866910999546691584 |
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| author | Wareham, W. Callum Sivak, David A. |
| author_facet | Wareham, W. Callum Sivak, David A. |
| contents | Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use linear-response theory to design efficient protocols exercising dynamic control of trap center and stiffness in a model of driven F1-ATPase. We find that the key design principles of an efficient protocol can be satisfied either by dynamic control of both parameters or by dynamic control of a single parameter and a good static choice for the second. These results illustrate that accessing a new degree of dynamic control provides varying performance improvements in different systems. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2410_24122 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Multiparameter optimal control of F1-ATPase Wareham, W. Callum Sivak, David A. Biological Physics Statistical Mechanics Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use linear-response theory to design efficient protocols exercising dynamic control of trap center and stiffness in a model of driven F1-ATPase. We find that the key design principles of an efficient protocol can be satisfied either by dynamic control of both parameters or by dynamic control of a single parameter and a good static choice for the second. These results illustrate that accessing a new degree of dynamic control provides varying performance improvements in different systems. |
| title | Multiparameter optimal control of F1-ATPase |
| topic | Biological Physics Statistical Mechanics |
| url | https://arxiv.org/abs/2410.24122 |